Intriguing connection between diet, eye health and lifespan

“The finding that the eye itself, at least in the fruit fly, can directly regulate lifespan was a surprise to us”

09-Jun-2022 - Researchers from the Buck Institute have demonstrated for the first time a link between diet, circadian rhythms, eye health and lifespan in Drosophila. Publishing in the June 7, 2022 issue of Nature Communications, they additionally and unexpectedly found that processes in the fly eye are ...

A secreted signature of aging cells

20-Jan-2020 - Senescent cells undergo an irreversible and permanent arrest of cell division and are hallmarks of both the aging process and multiple chronic diseases. Senescent cells - and more importantly the factors they secrete, known collectively as the senescence-associated secretory phenotype (SASP) - ...

Buck researchers identify new 'druggable' target for sporadic Parkinson's disease

03-Jun-2016 - Research at the Buck Institute shows the same mechanisms that lead to neuronal cell death in mice genetically fated to develop Parkinson's disease (PD) are involved in the much more common sporadic form of the age-related, neurodegenerative disorder that robs people of the ability to move ...

Comprehensive study using bioinformatics predicts the molecular causes of many genetic diseases

Research spearheaded at Buck Institute results in a web-based tool available to other scientists

12-Feb-2010 - It is widely known that genetic mutations cause disease. What are largely unknown are the mechanisms by which these mutations wreak havoc at the molecular level, giving rise to clinically observable symptoms in patients. Now a new study using bioinformatics, led by scientists at the Buck ...

DNA-damaged cells communicate with neighbors to let them know they're in trouble

Buck Institute research has implications in aging and cancer

15-Jul-2009 - When cells experiencing DNA damage fail to repair themselves, they send a signal to their neighbors letting them know they're in trouble. The discovery, which shows that a process dubbed the DDR (DNA Damage Response) also controls communication from cell to cell, has implications for both cancer ...

Novel technology opens the door to the understanding of and possible treatments for obesity, diabetes, ageing and cancer

Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics

08-Oct-2008 - Seahorse Bioscience announced the release of the first ever analytical instrument for the kinetic measurement of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells in a 96 well microplate. For the past 75 years tools for measuring cellular bioenergetics have been relatively ...