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8,302 Current news from the industry healthcare

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Comprehensive genetic characterization of primary immunodeficiency

Genetics of primary immunodeficiencies on an unprecedented scale explored

08-May-2020 - So-called primary immunodeficiencies (PID) are a group of rare immune system deficiencies, which are based on a malfunction of the immune system. Among other things, they can lead to recurring and often life-threatening infections in those affected. In addition, patients have an increased risk of ...

genome analysis immune system primary immunodeficiencies
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Protective shield: How pathogens withstand acidic environments in the body

Cell wall as a therapeutic target for the treatment of dangerous MRSA infections

07-May-2020 - Certain bacteria, including the dangerous nosocomial pathogen MRSA, can protect themselves from acidic conditions in our body and thus ensure their survival. Researchers at the Biozentrum of the University of Basel have now elucidated an important mechanism in this process. A transport protein ...

bacteria hospital germs Methicillin-resistant Staphylococcus aureus
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Using mini colons to detect functional differences and weaknesses of colorectal cancer

Pooled in vitro and in vivo CRISPR-Cas9 screening identifies tumor suppressors in human colon organoids

07-May-2020 - One of the main features of colorectal cancer is that there are considerable differences between the tumors of individual patients - at genetic level and hence in terms of the response to treatment too. Researchers from the German Cancer Consortium (DKTK) have developed a method that allows these ...

cancer colorectal cancer CRISPR +2
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Ticks can transmit the bacterium Coxiella burnetii

Pathogen of Q fever detected in the feces of ticks

06-May-2020 - Researchers from the Fraunhofer Institute for Cell Therapy and Immunology IZI were able to prove that ticks transmit the Q fever pathogen. Tick feces, which contain high concentrations of the bacteria, play a particularly important role in this process. Q fever is a reportable disease in the EU. ...

bacteria Coxiella burnetii Q fever +1
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Breakthrough in molecular machines

Researchers have succeeded to obtain control of the molecular machines, which in the future may enable them to perform controlled movements

06-May-2020 - Molecules are some of life's most basic building blocks. When they work together in the right way, they become molecular machines that can solve the most amazing tasks. They are essential for all organisms by, for example, maintaining a wide range of cellular functions and mechanisms. What if you ...

coatings drug release molecular machines
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Bern coronavirus clone goes "viral"

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

05-May-2020 - Researchers in virology and veterinary bacteriology at the University of Bern have cloned the novel coronavirus (SARS-CoV-2). The synthetic clones are being used by research groups worldwide to test corona samples, find antiviral drugs and develop vaccines as quickly as possible. The method ...

cloning coronaviruses SARS-CoV-2
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Aging and diet lead to proteome changes in the intestinal epithelium

Study provide a complete picture of the spatial organization of the small intestine proteome

05-May-2020 - The small intestine is one of the most important interfaces between the environment and our body. It is responsible for nutrient absorption but also forms a barrier against potentially harmful environmental cues. A research team, led by researchers from the Leibniz Institute on Aging – Fritz ...

ageing intestines proteomics
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Antibodies from llamas could help in fight against COVID-19

Scientists were inspired by antibodies produced by a llama named Winter

05-May-2020 - The hunt for an effective treatment for COVID-19 has led one team of researchers to find an improbable ally for their work: a llama named Winter. The team -- from The University of Texas at Austin, the National Institutes of Health and Ghent University in Belgium -- reports their findings about a ...

antibodies coronaviruses Covid-19 +1
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Preventing metastasis - an antibody with therapeutic potential

New principle for slowing down the metastatic dissemination of cancer cells

04-May-2020 - A receptor in the cell layer that lines the blood vessels from the inside stimulates both the formation of new blood vessels in tumors and metastasis. Scientists at the German Cancer Research Center in Heidelberg (DKFZ) and the Mannheim Medical Faculty of the University of Heidelberg have ...

antibodies cancer metastasis
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Improving immunotherapy for cancer

Cause for the lack of immune defense against tumors discovered

04-May-2020 - One of the reasons why cancer develops is because regulatory cells inhibit the body's immune defense. Researchers under the helm of the Technical University of Munich (TUM) have discovered a mechanism for identifying regulatory cells in tumor tissue that suppress an immune response. Their ...

cancer immune cells immunotherapies