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Marine alga from the Kiel Fjord discovered as a remedy against infections and skin cancer

Research group successfully applies bioinformatics methods and machine learning in marine drug discovery

06-Jul-2020

Marine organisms and their microbial symbionts are invaluable sources of new medicines for human diseases. Natural products from the sea have four times higher potential to become medicines than any other natural or synthetic compound. But the discovery process is long, risky and costly. Using ...

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How ApoE4 endangers the brain

A potential new approach to Alzheimer’s therapeutics?

06-Jul-2020

Apolipoprotein E4 is considered the most important genetic risk factor for Alzheimer’s disease. A group of researchers, led by MDC scientist Thomas Willnow, has now discovered how ApoE4 can damage the brain. Apolipoprotein E (ApoE) is kind of like a delivery service for the human brain. It ...

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Why and how we age

A low level of the stress hormone cortisol contributes to the ageing process

03-Jul-2020

Why do we age? What exactly is happening in our bodies? And can we do anything about it? Mankind has sought answers to these questions since time immemorial. While the pharmaceutical scientists Alexandra K. Kiemer and Jessica Hoppstädter from Saarland University are not claiming to have solved ...

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New method reveals how the Parkinson's disease protein damages cell membranes

The method makes it possible to study tiny quantities of biological molecules without using fluorescent markers

03-Jul-2020

In sufferers of Parkinson's disease, clumps of α-synuclein (alpha-synuclein), sometimes known as the 'Parkinson's protein', are found in the brain. These destroy cell membranes, eventually resulting in cell death. Now, a new method developed at Chalmers University of Technology, Sweden, reveals ...

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Dust mite allergens trigger inflammatory responses

Dust mite allergens activate the pulmonary immune system, thereby triggering allergies

02-Jul-2020

A research team at MedUni Vienna, working in cooperation with the Johns Hopkins University in Baltimore, has discovered how certain dust mite allergens activate a well-known inflammatory factor – serum amyloid A protein –and can thus “trim” the lung tissue “in the direction of allergy”. The ...

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Researchers identify multiple molecules that shut down SARS-Cov-2 polymerase reaction

A library of molecules with unique structural and chemical features inhibit the novel coronavirus polymerase, a key drug target for COVID-19

02-Jul-2020

SARS-CoV-2, the coronavirus causing the global COVID-19 pandemic, uses a protein called polymerase to replicate its genome inside infected human cells. Terminating the polymerase reaction will stop the growth of the coronavirus, leading to its eradication by the human host's immune ...

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Cow's milk protein beta-lactoglobulin prevents allergies

New key molecule for the so-called protective farm effect

01-Jul-2020

Numerous studies have shown that growing up on a farm and drinking natural, unprocessed cow's milk in early childhood protects against the development of immunoglobulins E (IgE), which are responsible for allergy symptoms. A recent study led by Franziska Roth-Walter and Erika Jensen-Jarolim from ...

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New approach drives bacteria to produce potential antibiotic, antiparasitic compounds

Researchers used a variety of techniques, including genome mining, to identify bacteria that produce defensive compounds in response to hormone exposure

30-Jun-2020

Researchers have developed a method to spur the production of new antibiotic or antiparasitic compounds hiding in the genomes of actinobacteria, which are the source of drugs such as actinomycin and streptomycin and are known to harbor other untapped chemical riches. The researchers wanted to ...

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Circular RNA makes fruit flies live longer

One step closer to the mysterious circRNAs

29-Jun-2020

Ribonucleic acid, or RNA, is part of our genetic code and present in every cell of our body. The best known form of RNA is a single linear strand, of which the function is well known and characterized. But there is also another type of RNA, so-called “circular RNA”, or circRNA, which forms a ...

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Children of academics exhibit more stress

If the stress hormone level is elevated for a long time, this can be seen in the hair

29-Jun-2020

Starting university is an exciting phase for everyone. However, children from academic households exhibit significantly more stress during this period than those from non-academic families. A Swiss-German research team has found this out by analysing the hair of female first-year students. Study ...

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