21-Sep-2015 - Beckman Coulter Genomics

University of Copenhagen and Beckman Coulter Genomics collaborate to unravel how mutations rewire cancer cells

Beckman Coulter Genomics announces the publishing of studies detailing the early results of the strategic collaboration between Beckman Coulter Genomics (BCG) and the Linding Lab at UCPH, Biotech Research & Innovation Centre. By developing advanced algorithms to integrate data from quantitative mass-spectrometry and next generation sequencing of tumor samples, the researchers have been able to uncover cancer related changes to phospho-signaling networks at a global scale.

Using the exome sequencing services pipeline developed at BCG, researchers from the Universities of Copenhagen, Yale, Zurich, Rome and Tottori have, in two landmark studies unraveled how mutations such as those acquired in cancer, target and damage the protein signaling networks within human cells on an unprecedented scale.

This new breakthrough allows researchers to identify the effects of mutations on the function of proteins in cancer for individual patients, even if those mutations are very rare. “The identification of distinct changes within our tissues that help predict and treat cancer is a major step forward and we are confident it can aid in the development of novel therapies and screening techniques”, said lead researcher, Professor Dr. Rune Linding, Biotech Research & Innovation Centre at UCPH.

These studies highlight the importance of integrating genomics data in cancer biology. High quality sequencing and bioinformatics as provided by BCG is a vital step in identifying and characterizing cancerous mutations. Services available at BCG such as whole exome sequencing, variant analysis, and RNASeq expression analysis provide research groups such as BRIC and the Linding Laboratory with access to the resources and expertise needed to support these important research efforts.

It is becoming increasingly apparent that the genetic basis for each tumor is subtly different. This realization has led to healthcare centers spending millions of dollars sequencing individual patients and their tumors with the aim of utilizing this patient specific information to develop tailored, personalized therapies, with much greater efficacy. It is hoped that the novel tools described in these studies together with best-in-class driver technologies such as BCG services can provide much needed assistance to clinicians and researchers worldwide in interpreting this data.

  • Pau Creixell, Antonio Palmeri, Chad J. Miller, Hua Jane Lou, Cristina C. Santini, Morten Nielsen, Benjamin E. Turk, Rune Linding; "Unmasking Determinants of Specificity in the Human Kinome"; Cell; 2015
  • Pau Creixell, Erwin M. Schoof, Craig D. Simpson, James Longden, Chad J. Miller, Hua Jane Lou, Lara Perryman, Thomas R. Cox, Nevena Zivanovic, Antonio Palmeri, Agata Wesolowska-Andersen, Manuela Helmer-Citterich, Jesper Ferkinghoff-Borg, Hiroaki Itamochi, Bernd Bodenmiller, Janine T. Erler, Benjamin E. Turk, Rune Linding; "Kinome-wide Decoding of Network Attacking Mutations Rewiring Cancer"; Cell; 2015
Facts, background information, dossiers
  • Yale University
  • Universität Zürich
More about Beckman Coulter
More about University of Copenhagen
  • News

    Malaria pathogens under the X-ray microscope

    Malaria is one of the most threatening infectious diseases in the world. An international team has now been able to investigate malaria pathogens in red blood cells in vivo using the BESSY II X-ray microscope and the ALBA and ESRF synchrotron sources. The scientists reveal the mechanisms us ... more

    New discoveries map out CRISPR-Cas defence systems in bacteria

    With the aid of highly advanced microscopes and synchrotron sources, researchers from the University of Copenhagen have gained seminal insight into how bacteria function as defence mechanisms against attacks from other bacteria and viruses. The study, which has just been published in the jo ... more

    Little Heaps of Silver, All Wrapped Up

    Nanoclusters are little “heaps” of a few atoms that often have interesting optical properties and could become useful probes for imaging processes in areas such as biomedicine and diagnostics. In the journal Angewandte Chemie, researchers have introduced a nanocluster of 16 silver atoms sta ... more