Quinten identifies a combination of two synergistic markers that predicts a favorable response to treatment in breast cancer

27-Feb-2013 - France

Quinten announced the identification of two discriminating biological marker candidates which are indicative of a favorable response to treatment in women suffering from triple-negative breast cancer (TNBC). In the sub-group with both markers in combination, 86 per cent of women responded to treatment with Panitumumab plus Fec 100, followed by Docetaxel, with complete disappearance of the tumor (equating to a full pathological response on Chevallier’s classification). Only 47 per cent of women in the total population examined during Phase II testing showed a similar response to treatment.
Using its proprietary Q-Finder algorithm, Quinten analyzed 200 biological variables relating to samples taken from 47 TNBC patients, provided by the Centre Jean Perrin in Clermont-Ferrand, which is led by Professor J Dauplat. The biological markers which have been identified confirm and build on results already found by teams working at the center under Professor Nabholtz, who is responsible for the medical and clinical research departments and Professor Penault-Lorca, Head of Biopathology and Director of the 4677 ERTICa university research team (Equipe de recherche sur les traitements individualises du cancer [personalised cancer treatment research team]) at the University of Auvergne.
In cancers showing a mixed basal/luminal phenotype, among patients with an EFGR score of more than 80, combined with a cytokeratin 8/18 percentage in excess of 20, the response rate to treatment is almost double (1.83 times) the overall rate for women suffering from TNBC. These patients represent approximately 30 per cent of women with TNBC.

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