Lung Diseases

News Lung Diseases

• New lung 'organoids' in a dish mimic features of full-size lung
  

  New lung "organoids"--tiny 3-D structures that mimic features of a full-sized lung--have been created from human pluripotent stem cells by researchers at Columbia University Medical Center (CUMC). The team used the organoids to generate models of human lung diseases in a lab dish, which could be use more

• Nanoparticle Exposure Can Awaken Dormant Viruses
  

  Nanoparticles from combustion engines can activate viruses that are dormant in in lung tissue cells. This is the result of a study by researchers of Helmholtz Zentrum München, a partner in the German Center for Lung Research (DZL). To evade the immune system, some viruses hide in cells of their hos more

• Multi-drug resistant infection spreading globally among cystic fibrosis patients

  A multi-drug resistant infection that can cause life-threatening illness in people with cystic fibrosis (CF) and can spread from patient to patient has spread globally and is becoming increasingly virulent, according to new research. The study, led by the University of Cambridge and the Wellcome Tru more

Videos Lung Diseases

New Lung “Organoids” In a Dish Mimic Features of Full-Size Lung

Researchers at Columbia University Medical Center have developed three-dimensional lung bud "organoids" from human pluripotent stem cells. The "mini organs" could be used to model lung diseases such as pulmonary fibrosis and respiratory syncytial virus infection.The research was carried out in t ... more

Publications Lung Diseases

• Role of efflux transporters in the absorption, distribution and elimination in rodents of a novel PDE4 inhibitor, CHF6001

  Publication date: 30 March 2018 Source:European Journal of Pharmaceutical Sciences, Volume 115 Author(s): V. Cenacchi, M. Salvadori, B. Riccardi, G. Brogin, A. Ghiglieri, M. Messina, G. Imre, P. Puccini CHF6001 is a new and potent PDE4 inhibitor for the treatment of human lung more

• Human pulmonary 3D models for translational research

  Lung diseases belong the major causes of death worldwide. Recent innovative methodological developments now allow more and more for the use of primary human tissue and cells to model such diseases. In this regard, the review covers bronchial air‐liquid interface cultures, precision cut lung slice more

• Vascularized grafts for lungs

  Lung Disease Lung diseases are a major cause of death worldwide, and therapies for rebuilding damaged lung tissue are urgently needed. However, because the lung is such a complex organ, creating effective therapies is difficult. Dorrello et al. describe a way to remove pulmonary epithelial cells more