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Saripidem



Saripidem
Systematic (IUPAC) name
N-[(2-(4-chlorophenyl)imidazo[3,2-a]pyridin-3-yl)methyl]-N-methylbutanamide
Identifiers
CAS number 103844-86-6
ATC code  ?
PubChem 3058746
Chemical data
Formula C19H20ClN3O 
Mol. mass 341.835 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Saripidem is a sedative and anxiolytic drug in the imidazopyridine family, which is related to the better known drugs zolpidem and alpidem.

Additional recommended knowledge

Saripidem has a similar pharmacological profile to the benzodiazepine family of drugs including sedative and anxiolytic properties, but its chemical structure is quite different to that of the benzodiazepine drugs, and saripidem is described as a nonbenzodiazepine.

The mechanism of action by which saripidem produces its sedative and anxiolytic effects is by modulating the benzodiazepine binding site on GABAA receptors, however unlike many older GABAA agonists, saripidem is highly subtype selective and binds primarily to the ω1 subtype.[1]

References

  1. ^ Sanger DJ (1995). "Behavioural effects of novel benzodiazepine (omega) receptor agonists and partial agonists: increases in punished responding and antagonism of the pentylenetetrazole cue". Behavioural Pharmacology 6 (2): 116–126. PMID 11224318.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Saripidem". A list of authors is available in Wikipedia.
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