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STAT1




Signal transducer and activator of transcription 1, 91kDa
STAT1 bound to DNA
Available structures: 1bf5, 1yvl
Identifiers
Symbol(s) STAT1; DKFZp686B04100; ISGF-3; STAT91
External IDs OMIM: 600555 MGI: 103063 Homologene: 21428
RNA expression pattern

Additional recommended knowledge

More reference expression data

Orthologs
Human Mouse
Entrez 6772 20846
Ensembl ENSG00000115415 ENSMUSG00000026104
Uniprot P42224 Q3TW11
Refseq NM_007315 (mRNA)
NP_009330 (protein)
NM_009283 (mRNA)
NP_033309 (protein)
Location Chr 2: 191.54 - 191.59 Mb Chr 1: 52.07 - 52.1 Mb
Pubmed search [1] [2]

STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I or type II interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon Stimulated Response Element) promoter element.[1] In either case, binding of the promoter element leads to an increased expression of ISG (Interferon Stimulated Genes).

References

  1. ^ Michael G. Katze, Yupeng He & Michael Gale, et al (2002). "Viruses and interferon: a fight for supremacy.". Nature Reviews Immunology 2: 675-87. doi:10.1038/nri888. PMID 12209136.

Further reading

  • Cebulla CM, Miller DM, Sedmak DD (2000). "Viral inhibition of interferon signal transduction.". Intervirology 42 (5-6): 325-30. PMID 10702714.
  • Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges.". Gene 285 (1-2): 1-24. PMID 12039028.
  • Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87-94. PMID 15638726.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "STAT1". A list of authors is available in Wikipedia.
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