My watch list  

Primitive knot

Primitive knot
Gray's subject #6 47
Days 17
Dorlands/Elsevier k_04/12471954

The primitive knot (or Primitive node) is the organizer for gastrulation in vertebrates.


  • In birds it is known as "Hensen's node", and is named after its discoverer Victor Hensen.
  • In amphibians, it is known as "Spemann's organizer", and is named after Hans Spemann (who, with Mangold, first identified the organizer in 1924.[1])


The primitive knot starts as a regional knot of cells that forms on the blastodisc immediately anterior to where the outer layer of cells will begin to migrate inwards - an area known as the primitive streak. Posterior to the node is the primitive pit, where the cells of the epiblast (the upper layer of embryonic cells) initially begin to invaginate. This invagination expands posteriorly into the primitive groove as the cells layers continue to move into the space between the embryonic cells and the yolk and differentiate the embryo into the germ layers - endoderm, mesoderm, and ectoderm. The primitive knot migrates posteriorly as gastrulation proceeds, eventually being absorbed into the tail bud.

The cells of the primitive knot secrete many cellular signals essential for gastrulation - including Fibroblast Growth Factors, Sonic hedgehog, and retinoic acid. Differential secretion of factors by the node also causes development of the right-left axis in the embryo.


  1. ^ Garcia-Fernàndez J, D'Aniello S, Escrivà H (2007). "Organizing chordates with an organizer". Bioessays 29 (7): 619-24. doi:10.1002/bies.20596. PMID 17563072.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Primitive_knot". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE