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P2Y12




Purinergic receptor P2Y, G-protein coupled, 12
Identifiers
Symbol(s) P2RY12; ADPG-R; HORK3; P2T(AC); P2Y(AC); P2Y(ADP); P2Y(cyc); P2Y12; SP1999
External IDs OMIM: 600515 MGI: 1918089 Homologene: 11260
Orthologs
Human Mouse
Entrez 64805 70839
Ensembl ENSG00000169313 ENSMUSG00000036353
Uniprot Q9H244 Q546L4
Refseq NM_022788 (mRNA)
NP_073625 (protein)
NM_027571 (mRNA)
NP_081847 (protein)
Location Chr 3: 152.54 - 152.59 Mb Chr 3: 59.3 - 59.35 Mb
Pubmed search [1] [2]

Additional recommended knowledge

In the field of molecular biology, the P2Y12 protein is a chemoreceptor for adenosine diphosphate (ADP) and is found on the cell surface of blood platelet cells.[1][2]

The P2Y12 protein belongs to a group of G protein-coupled purinergic receptors[3] and is an important regulator in blood platelet coagulation.[4]


The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.[5]


Clinical significance

The drug clopidogrel binds to this receptor and is marketed as a platelet anticoagulant.[1] In an April 2006 article, a team of researchers published a study of the role of platelet-transported serotonin in liver regeneration in which this method of platelet anticoagulant therapy was used.[6]

References

  1. ^ a b Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, Yang RB, Nurden P, Nurden A, Julius D, Conley PB (2001). "Identification of the platelet ADP receptor targeted by antithrombotic drugs". Nature 409 (6817): 202-7. doi:10.1038/35051599. PMID 11196645.
  2. ^ Nicholas RA (2001). "Identification of the P2Y(12) receptor: a novel member of the P2Y family of receptors activated by extracellular nucleotides". Mol. Pharmacol. 60 (3): 416-20. PMID 11502870.
  3. ^ Murugappa S, Kunapuli SP (2006). "The role of ADP receptors in platelet function". Front. Biosci. 11: 1977-86. doi:10.2741/1939. PMID 16368572.
  4. ^ Dorsam RT, Kunapuli SP (2004). "Central role of the P2Y12 receptor in platelet activation". J. Clin. Invest. 113 (3): 340-5. doi:10.1172/JCI200420986. PMID 14755328.
  5. ^ Entrez Gene: P2RY12 purinergic receptor P2Y, G-protein coupled, 12.
  6. ^ Lesurtel M, Graf R, Aleil B, Walther DJ, Tian Y, Jochum W, Gachet C, Bader M, Clavien PA (2006). "Platelet-derived serotonin mediates liver regeneration". Science 312 (5770): 104-7. doi:10.1126/science.1123842. PMID 16601191.


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "P2Y12". A list of authors is available in Wikipedia.
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