An odontogenic keratocyst is a benign but locally aggressive developmental odontogenic cyst. It is thought to arise from the dental lamina. Pain is usually not associated with odontogenic keratocysts until swelling occurs. It commonly affects the posterior mandible. Multiple odontogenic keratocysts are associated with nevoid basal cell carcinoma syndrome.
recently it is named Keratocystic Odontogenic Tumour (KCOT)in both solitary cases and syndrome related cases.
ref. WHO Classification of Head and Neck Tumours.2005 WHO press
the neoplastic transformation is reported, few cases of SSC have been reported, along with several cases of ameloblastic transformation in the epithelium of OKCT.
Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.