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Necrosis (in Greek Νεκρός = Dead) is the name given to accidental death of cells and living tissue. It begins with cell swelling, chromatin digestion, and disruption of the plasma membrane and organelle membranes. Late necrosis is characterized by extensive DNA hydrolysis, vacuolation of the endoplasmic reticulum, organelle breakdown, and cell lysis. The release of intracellular content after plasma membrane rupture is the cause of inflammation in necrosis.
In contrast to apoptosis, cleanup of cell debris by phagocytes of the immune system is generally more difficult, as the disorderly death generally does not send cell signals which tell nearby phagocytes to engulf the dying cell. This lack of signaling makes it harder for the immune system to locate and recycle dead cells which have died through necrosis than if the cell had undergone apoptosis.
Additional recommended knowledge
There are many causes of necrosis including prolonged exposure to injury, infection, cancer, infarction, poisons, and inflammation. Severe damage to one essential system in the cell leads to secondary damage to other systems, a so-called "cascade of effects". Necrosis can arise from lack of proper care to a wound site. Necrosis is accompanied by the release of special enzymes, that are stored by lysosomes, which are capable of digesting cell components or the entire cell itself. The injuries received by the cell may compromise the lysosome membrane, or may initiate an disorganized chain reaction which causes the release in enzymes. Unlike apoptosis, cells that die by necrosis may release harmful chemicals that damage other cells. In biopsy, necrosis is halted by fixation or freezing. A main cause of necrosis is from the Brown Recluse Spiders, who's venom causes significant cutaneous injureis with tissue loss and necrosis.
There are seven distinctive morphologic patterns of necrosis:
Spider bites are cited as causing necrosis in some areas. These claims are widely disputed. In the US at least, only the bites of spiders in the genus Loxosceles or brown recluse have been proven to consistently cause necrosis. Many other spider species are claimed to cause necrosis but in most cases firm evidence is lacking. Partially this is because the early bite is often painless and the spider species cannot be identified.
Several species of spiders posess toxins proven to cause necrosis:
Spiders suspected of, but not shown to cause necrosis:
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Necrosis". A list of authors is available in Wikipedia.|