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Myelin oligodendrocyte glycoprotein



myelin oligodendrocyte glycoprotein
Identifiers
Symbol MOG
Entrez 4340
HUGO 7197
OMIM 159465
RefSeq NM_001008228
UniProt Q16653
Other data
Locus Chr. 6 p22-p21.3

Myelin Oligodendrocyte Glycoprotein (MOG) is a glycoprotein believed to be important in the process of myelinization of nerves in the central nervous system (CNS).

Additional recommended knowledge

The gene for MOG, found on chromosome 6, was first sequenced in 1995 [1]. It is a transmembrane protein expressed on the surface of oligodendrocyte cell and on the outermost surface of myelin sheaths.

Role in disease

Interest in MOG has centered on its role in demyelinating diseases, particularly multiple sclerosis (MS). Several studies have shown a role for antibodies against MOG in the pathogenesis of MS[2].

References

  1. ^  Roth, M.-P.; Malfroy, L.; Offer, C.; Sevin, J.; Enault, G.; Borot, N.; Pontarotti, P.; Coppin, H. The human myelin oligodendrocyte glycoprotein (MOG) gene: complete nucleotide sequence and structural characterization. Genomics 28: 241-250, 1995 PMID 8530032
  2. ^  Berger T, Rubner P, Schautzer F, Egg R, Ulmer H, Mayringer I, Dilitz E, Deisenhammer F, Reindl M. Antimyelin Antibodies as a Predictor of Clinically Definite Multiple Sclerosis after a First Demyelinating Event N Engl J Med. 2003 Jul 10;349(2):139-45. PMID 12853586
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Myelin_oligodendrocyte_glycoprotein". A list of authors is available in Wikipedia.
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