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Systematic (IUPAC) name
CAS number 1424-00-6
ATC code G03BB01
PubChem 15020
Chemical data
Formula C20H32O2 
Mol. mass 304.467 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Mesterolone is an orally applicable androgen, and DHT derivative. It is sold under the brand name Proviron, by Schering. In the late 70's and early 80's it was used with some success in controlled studies of men suffering from various forms of depression.

In one randomized, double-blind 4-week trial, 38 dysthymic men were administered 75mg daily. Itil & Colleagues reported an improvement of symptoms which included anxiety, lack of drive and desire. Next, they administered a high dose (450mg/day) or placebo in a 6-week randomized trial of 52 men with a mean age of 40 years, suffering from dysthymia, unipolar and bipolar depression. Both the mesterolone and placebo groups improved significantly and there were no statistically significant differences between the two groups. In this series of studies mesterolone lead to a significant decrease in LH and testosterone levels. This is probably as a result of the extremely high dose used. In another, 100mg mesterolone cipionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected.[1]

Mesterolone is a relatively weak androgen and rarely used for replacement therapies.[2]


  1. ^ Archives of Dermatological Research (1977), Testosterone levels and gonadotrophins in klinefelter's patients treated with injections of mesterolone cipionate
  2. ^ Human Reproduction Update (2004), Testosterone replacement therapy: current trends and future directions
  • Frances Morrison, Mary. (2000) Hormones, Gender and the Aging Brain: The Endocrine Basis of Geriatric Psychiatry, Page 134, Cambridge University Press. ISBN 0521653045.
  • Itil et al. The effects of mesterolone, a male sex hormone in depressed patients. 1984.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mesterolone". A list of authors is available in Wikipedia.
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