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Diacylglycerol lipase



diacylglycerol lipase, alpha
Identifiers
Symbol DAGLA
Alt. Symbols C11orf11
Entrez 747
HUGO 1165
RefSeq NM_006133
UniProt Q9Y4D2
Other data
Locus Chr. 11 q12.3
diacylglycerol lipase, beta
Identifiers
Symbol DAGLB
Entrez 221955
HUGO 28923
RefSeq NM_139179
UniProt Q8NCG7
Other data
Locus Chr. 7 p22.1
Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol.[1] It catalyzes the hydrolysis of diacylglycerol releasing a free fatty acid and monoacylglycerol.

Two separate genes encoding DGL enzymes have been cloned, termed DGLα (DAGLA) and DGLβ (DAGLB), that share 33% sequence identity.

Additional recommended knowledge

Inhibitors

The enzyme has been described to be inhibited selectively by two agents, RHC80267 and tetrahydrolipstatin.

References

  1. ^ Bisogno, T. et al. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J. Cell. Biol. 2003 (163)3:463. Article
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Diacylglycerol_lipase". A list of authors is available in Wikipedia.
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