My watch list
my.bionity.com  
Login  

Bethanechol



Bethanechol
Systematic (IUPAC) name
2-carbamoyloxypropyl-trimethyl-ammonium
Identifiers
CAS number 674-38-4
ATC code N07AB02
PubChem 2370
DrugBank APRD00051
Chemical data
Formula C7H17N2O2 
Mol. mass 161.222 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

C(US)

Legal status
Routes oral, subcutaneous

Bethanechol (be-Than-e-kol [key]) is a parasympathomimetic choline ester that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. Its chemical structure is 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-1-propanaminium. Unlike acetylcholine, bethanechol is not hydrolyzed by cholinesterase and will therefore have a long duration of action.

Additional recommended knowledge

Bethanechol is sometimes given orally or subcutaneously to treat urinary retention resulting from general anesthetic or diabetic neuropathy of the bladder, or to treat gastrointestinal atony (lack of muscular tone). The muscarinic receptors in the bladder and gastrointestinal tract stimulate contraction of the bladder and expulsion of urine, and increased gastrointestinal motility, respectively. Bethanechol should be used to treat these disorders only after obstruction is ruled out as a possible cause.

Use of bethanechol, as well as all other muscarinic receptor agonists, is contraindicated in patients with asthma, coronary insufficiency, peptic ulcers, and incontinence. The parasympathomimetic action of this drug will exacerbate the symptoms of these disorders.

Bethanechol is sold under the brand names Duvoid (Roberts), Myotonachol (Glenwood), and Urecholine (Merck Frosst).

Sources

  • Katzung, Bertram G. Basic and Clinical Pharmacology, 9th ed. (2004). ISBN 0-07-141092-9
  • Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
  • Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Bethanechol". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE