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Anti-sp100 antibodies

Anti-sp100 antibodies are found in association with primary biliary cirrhosis.^[1] The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis. 20-30% of patients suffering from primary biliary cirrhosis sp100 Abs.

Immunodominant regions of sp100

antigenic region 1 - positions 296-311 - Sequence (I K K E K P F S N S K V E C Q A)
antigenic region 2 - positions 332-351 - Sequence (E G S T D V D E P L E V F I S A P R S E)

(Bolded areas represent the core epitope)^[2]

^ Szostecki C, Guldner HH, Netter HJ, Will H (1990). "Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis". J. Immunol. 145 (12): 4338-47. PMID 2258622.
^ Blüthner M, Schäfer C, Schneider C, Bautz FA (1999). "Identification of major linear epitopes on the sp100 nuclear PBC autoantigen by the gene-fragment phage-display technology". Autoimmunity 29 (1): 33-42. PMID 10052683.

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