Cancer Genes

In a paper in the journal “Science”, researchers from the Vienna BioCenter combine cutting-edge technologies to decipher regulatory functions of important cancer genes. Key to this success is an innovative method called “SLAMseq”, which allows the direct detection of sudden changes in gene expressio more

A new study from Michigan State University makes inroads in learning to "read" the genome, a key goal of modern biology. The results show that the DNA content of our genomes resembles a complex biological language, composed of coding regions and regulatory regions. Although protein-coding regions in more

Results of a new laboratory study by Johns Hopkins Kimmel Cancer Center researchers suggests that some rare "missense" mutations in the HER2 gene are apparently not -- on their own -- capable of causing breast cancer growth or spread. In a related finding, the research team said such mutations, whic more

by Daniel Munro, Dario Ghersi, Mona Singh A major goal of cancer genomics is to identify somatic mutations that play a role in tumor initiation or progression. Somatic mutations within transcription factors are of particular interest, as gene expression dysregulation is widespread in cancers. The more

Analysis of triangular motifs in protein interaction networks and their implications to protein ages and cancer genesHyeonseong Jeon; Suh-Ryung Kim; Dougu Nam; Yun Joo YooInternational Journal of Data Mining and Bioinformatics, Vol. 19, No. 4 (2017) pp. 340 - 365Proteins interact with each other to more

Abstract Although the catalog of cancer-associated mutations in protein-coding regions is nearly complete for all major cancer types, an assessment of regulatory changes in cancer genomes and their clinical significance remain largely preliminary. Adopting bottom-up approach, we quantify the effect more