Revolutionary Breakthrough: A Drug Slows Down Leukaemia Progression by Blocking Cancer-Causing Genes

Scientists demonstrate the therapeutic value of a compound that inhibits oncogene translation

20-Jul-2023 - In a remarkable new development, scientists at the Department of Cancer Research (DoCR) at the Luxembourg Institute of Health (LIH) have demonstrated the powerful impact of a drug in slowing down the progression of leukaemia by blocking the activation of cancer-causing genes. The findings, ...

Global breast cancer research makes significant findings

A global study led by the University of Otago has discovered a gene, that when modified, could reduce the risk of breast cancer

03-Jan-2023 - The discovery, led by Associate Professor Logan Walker, of the Department of Pathology and Biomedical Science, Christchurch, also opens the door to the development of a risk-reducing drug – a project which has already received funding and will also be led by Otago University. The initial study ...

Scientists characterise cancer genes using ground-breaking new method

09-Apr-2018 - In a paper in the journal “Science”, researchers from the Vienna BioCenter combine cutting-edge technologies to decipher regulatory functions of important cancer genes. Key to this success is an innovative method called “SLAMseq”, which allows the direct detection of sudden changes in gene ...

Do genes express themselves through poetry?

11-May-2016 - A new study from Michigan State University makes inroads in learning to "read" the genome, a key goal of modern biology. The results show that the DNA content of our genomes resembles a complex biological language, composed of coding regions and regulatory regions. Although protein-coding regions ...

Rare Her2 mutations may not always spur breast cancers on their own

12-Nov-2015 - Results of a new laboratory study by Johns Hopkins Kimmel Cancer Center researchers suggests that some rare "missense" mutations in the HER2 gene are apparently not -- on their own -- capable of causing breast cancer growth or spread. In a related finding, the research team said such mutations, ...

Team develops strategy to determine how non-coding variants contribute to disease risk

25-Sep-2015 - Researchers describes a strategy for meeting one of today's most significant challenges in genomic medicine - determining whether a specific DNA variant in the non-protein-coding genome is the actual disease-causing variant of an associated disease risk. The report from a multi-institutional team ...

UMC Utrecht researchers discover new breast cancer gene

11-Aug-2014 - Women with a mutation of the MEN1 gene have a higher risk of developing breast cancer. The disease also affects them at a younger age. These findings from research at the University Medical Center (UMC) Utrecht were published in the New England Journal of Medicine. MEN1 is the acronym for ...

Decision circuit of cancer metastasis

Rice U. research reveals 3-way genetic switch for cancer metastasis

28-Oct-2013 - Cancer researchers from Rice University have deciphered the operating principles of a genetic switch that cancer cells use to decide when to metastasize and invade other parts of the body. The study found that the on-off switch's dynamics also allows a third choice that lies somewhere between ...

Breast cancer risk gene discovery fast tracked by new technology

03-Apr-2012 - An international team of researchers led by the University of Melbourne has used new technology to fast track the discovery of a breast cancer risk gene and could assist in the discovery of other cancer genes.Professor Melissa Southey of the Genetic Epidemiology Laboratory, Department of ...

Researchers shine light on how some melanoma tumors evade drug treatment

29-Nov-2010 - Researchers shine light on how some melanoma tumors evade drug treatment Findings pinpoint a critical gene involved in melanoma growth, provide a framework for discovering ways to tackle cancer drug resistance The past year has brought to light both the promise and the frustration of developing ...