Hubert Tseng, Aleksandra Velkova-Krei

Magnetic 3D Cell Culturing – Simple and Effective Technology with Wide Range of Applications

Effective Tool for the Formation of Spheroids for Drug Discovery, Stem Cell and Basic Research

Biomedical research has gravitated towards three-dimensional (3D) cell culture in order to improve accuracy over traditional two-dimensional (2D) monolayers. There are several 3D cell culture platforms on the market, and among all of them are magnetic levitation and magnetic 3D bioprinting. The principle behind these methods is the magnetisation of cells with a nanoparticle assembly, NanoShuttle™. Magnetised cells can then be aggregated by either: magnetic levitation, where cells are levitated by a magnet above the plate to aggregate away from a stiff substrate; or magnetic 3D bioprinting, where cells are rapidly aggregated at the bottom of a CELLSTAR® cell-repellent plate with a magnetic drive below the plate. Once aggregated, these cells interact and self-assemble into a culture that recreates in vivo environments. The advantage of these 3D cell culture platforms over others is the utility of the magnetic forces in both rapidly forming cultures, as well as holding them in place while processing. Research from our lab and our users with this platform has shown no effect of NanoShuttle™ on cell health or function.

More about Greiner Bio-One
  • White papers

    Magnetic 3D Cell Culturing – Simple and Effective Technology with Wide Range of Applications

    Magnetic 3D cell culturing allows rapid development of three-dimensional models as well as co-culture of various cell lines more

  • Videos

    Comfortable and Efficient Pipetting

    Optimum Ergonomics and Performance Sapphire Pipettes are a variable volume range of air-displacement pipettes designed and built to deliver optimal performance, ergonomics, and robustness in day-to-day use. The lightweight design coupled with a special mechanism reduces pipetting forces and ... more

    Greiner Bio-One - Company movie


  • News

    Change at the top at Greiner Bio-One GmbH

    Jakob Breuer (51) has become the new Chief Technology Officer (CTO) of the Greiner Bio-One BioScience division in Frickenhausen. Breuer, an engineering graduate, was appointed to the post in April 2018, taking over from Rudi Vollmer, who is retiring after over 40 successful years at the com ... more

    Greiner Bio-One acquires 3D Cell Culture Technology assets from Nano3D Biosciences

    Greiner Bio-One North America, Inc. has acquired 3D Cell Culture Technology previously owned by Nano 3D Biosciences, Inc. As an international distributor of these products since 2016, Greiner Bio-One has now taken the initiative to become a premier provider of this technology worldwide. Mag ... more

    Greiner Bio-One - Invests EUR 500 million in USA

    Sophisticated technology is worth the money. With the invention and development of a product for the field of diagnostics, the Austrian company located in Kremsmünster has manufactured an impressive 5 billion VACUETTE® tubes for diagnostic examinations throughout the world since 1992. As ... more

  • Companies

    Greiner Bio-One GmbH

    Greiner Bio-One specialises in the development, production and distribution of high-quality plastic laboratory products. The company is a technology partner for laboratories, universities, research institutes, and the diagnostic, pharmaceutical and biotechnology industries. With the BioSci ... more

    Greiner Bio-One International GmbH

    Greiner Bio One International Greiner Bio-One International AG specialises in biotechnology, the diagnostic and pharmaceutical industries as well as in medical and in-vitro diagnostics. The entire product range as well as the production and distribution network of the Greiner family-owned c ... more

    Greiner Bio-One Vacuette Schweiz GmbH

    Greiner Bio-One International GmbH is an international medical technology company made up of four business divisions. Preanalytics develops innovative collection systems for human and veterinary samples that make the flow of daily routine tasks in hospitals, laboratories or doctors' surger ... more