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Cambridge scientists are part of a resolution revolution. Building powerful instruments that shatter the physical limits of optical microscopy, they are beginning to watch molecular processes as they happen, and in three dimensions. Here, Professor Clemens Kaminski describes how a new era of super-resolution microscopy has begun.
The developments earned inventors Eric Betzig and William E Moerner (USA) and Stefan Hell (Germany) the 2014 Nobel Prize for Chemistry, and are based on clever physical tricks that work around the problem of light diffraction.
Among the scientists in Cambridge who are using the techniques, Kaminski’s team in the Department of Chemical Engineering and Biotechnology designs and builds super-resolution microscopes to study Alzheimer’s disease. “The technology is based on a conceptual change, a different way of thinking about how we resolve tiny structures. By imaging blobs of light as separate points in time, we are able to discriminate them spatially, and thus prevent image blur.” Their work is funded by the Medical Research Council, Wellcome Trust, Alzheimers Research UK, the Engineering and Physical Sciences Research Council and the Leverhulme Trust.
Fighting cancer: Animal research at Cambridge
Animal research plays an essential role in our understanding of health and disease and in the development of modern medicine and surgical techniques. As part of our commitment to openness, this film examines how mice are helping the fight against cancer. It takes a in-depth look at the faci ... more
Killer T Cell: The Cancer Assassin
How does a Killer T Cell Kill its target?The new film captures the behaviour of cytotoxic T cells – the body’s ‘serial killers’ – as they hunt down and eliminate cancer cells before moving on to their next target. more
PARP-inhibitors: A New Generation of Cancer Drugs
First of new generation of cancer drugs granted European approvalA new drug for ovarian cancer, developed by researchers at the University of Cambridge and AstraZeneca, has become the first of new class of drugs, known as PARP-inhibitors, to be granted approval anywhere in the world. The dr ... more
Formation of quadruple helix DNA tracked in live human cells for the first time
The formation of four-stranded DNA has been tracked in living human cells, allowing scientists to see how it works, and its possible role in cancer. DNA usually forms the classic double helix shape discovered in 1953 - two strands wound around each other. Several other structures have been ... more
Scientists produce first open source all-atom models of full-length COVID-19 'S' protein
The virus SARS coronavirus 2 (SARS-CoV-2) is the known cause of coronavirus disease 2019 (COVID-19). The "spike" or S protein facilitates viral entry into host cells. Now a group of researchers from Seoul National University in South Korea, University of Cambridge in UK, and Lehigh Universi ... more
Nanoparticles used to transport anti-cancer agent to cells
Scientists from the University of Cambridge have developed a platform that uses nanoparticles known as metal-organic frameworks to deliver a promising anti-cancer agent to cells. Research led by Dr David Fairen-Jimenez, from the Cambridge Department of Chemical Engineering and Biotechnology ... more
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