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Protease Inhibitors

News Protease Inhibitors

  • The drug aprotinin inhibits entry of SARS-CoV2 in host cells

    In order for the SARS-CoV2 virus to enter host cells, its “spike” protein has to be cleaved by the cell’s own enzymes - proteases. The protease inhibitor aprotinin can prevent cell infection, as scientists at Goethe University, the University of Kent and the Hannover Medical School have now discover more

  • A new way to nip AIDS in the bud

    When new AIDS virus particles bud from an infected cell, an enzyme named protease activates to help the viruses mature and infect more cells. That's why modern AIDS drugs control the disease by inhibiting protease. Now, University of Utah researchers found a way to turn protease into a double-edged more

  • Advises on compassionate use of a new combination therapy for chronic hepatitis C

    The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has given an opinion on the use of a fixed-dose combination of ledipasvir and sofosbuvir in the treatment of chronic (long-term) hepatitis C virus (HCV) infection in a compassionate-use programme. Compassionate-use more

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Protease inhibitor pharmacology

Protease inhibitor pharmacology :For natural protease inhibitors, please see protease inhibitor (biology) Protease inhibitors (PIs) are a class of medication used to treat or prevent infection by virus es, including HIV and Hepatitis C . P ... more


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