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UV/VIS spectrophotometers: CTech FlowVPX In-line Variable Pathlength Spectroscopy System

CTech FlowVPX System – Variable Pathlength Spectroscopy for In-line Concentration Monitoring

Repligen Corporation

Rapid, Continuous Data Acquisition—12 QC-grade concentration measurements per minute

Broad Dynamic Range—concentration measurement from 0.1 mg/ml to 300 mg/ml without dilution

Increased accuracy—Multiple absorbance slope-based concentration measurements based on R2 ≥ 0.999

Real-time data for real-time decisions

Take control of your process with the CTech FlowVPX System. The in-line Slope Spectroscopy method enables users to monitor and optimize critical process parameters and make real-time decisions for enhanced product consistency and quality. Eliminate off-line measurements, out-of-spec results, and costly and time-consuming deviation reports. Slope-based measurements increase the efficiency of your process and avoid costly dilution and background correction steps.

Capable of making spectral and fixed-point measurements at wavelengths between 190 nm and 1100 nm with varying pathlengths, the System is adaptable to a wide range of sample types and the highest concentrations found in the biopharmaceutical industry. It can support lab-scale flow lines of 3 mm, pilot-scale flow lines of 10 mm, and production-scale flow lines of 22 mm. These processes include UF/DF, chromatography, mixing, and fill finish.

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CTech FlowVPX System – Variable Pathlength Spectroscopy for In-line Concentration Monitoring

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Only in-line uv-vis spectrophotometer using variable pathlength technology to continuously measure concentration

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The Fibrette is a stainless internal fiber optic that moves up and down during the process. Multiple Flow Cell sizes are available (3 mm, 1/2", 1")

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Variable Pathlength Technology makes the pathlength (l) the variable value, capturing multiple absorbance measurements in seconds.

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Variable Pathlength Technology makes the pathlength (l) the variable value, capturing multiple absorbance measurements in seconds.

Product classification

Applications

AAV viral titer
Antisense oligonucleotide concentration measurement
continuous chromatography
drug product formulation
OD600 monitoring
plasmid DNA purity ratio
polysorbate analysis
protein concentration measurement (A280)
quantitation of nucleic acids (DNA/RNA)
ultrafiltration/diafiltration monitoring

Product categories

concentration measurement devices
in-process spectrophotometer
process analytics instruments
slope spectroscopy
ultra-violet visible spectrophotometers
uv-vis spectroscopy
variable pathlength spectroscopy

Target Industries

Biotechnology
Pharma

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UV/VIS spectrophotometers: CTech FlowVPX In-line Variable Pathlength Spectroscopy System

CTech FlowVPX System – Variable Pathlength Spectroscopy for In-line Concentration Monitoring