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Mixed connective tissue disease

In medicine, mixed connective tissue disease, commonly abbreviated as MCTD, is a serious autoimmune disease, in which the body's defense system attacks itself. It is also known as Sharp syndrome.

Clinical features

MCTD combines features of polymyositis, systemic lupus erythematosus, and systemic scleroderma and is thus considered an overlap syndrome.

MCTD commonly causes:

It does not typically cause kidney disease or seizures.

Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody.[1]


  1. ^ Venables PJ (2006). "Mixed connective tissue disease". Lupus 15 (3): 132–7. PMID 16634365.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mixed_connective_tissue_disease". A list of authors is available in Wikipedia.
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