Pathology

Companies Pathology

microDimensions GmbH, Germany

microDimensions was founded as a spin-off of the Technische Universität München in 2011. As a provider of software solutions and services for the processing, visualization, and analysis of microscopic image data the company aims to speed up workflows for pathologists, medical laboratories and instit more

News Pathology

• Researchers use AI to establish molecular tumor classification and prognosis in patients with colorectal cancer
  

  Treating physicians need information about the molecular subtype of the tumor if they are to provide targeted therapy for colorectal carcinoma. A research team from University Hospital Zurich and the University of Oxford have now developed a method to predict the molecular classification of colorect more

• In the fight against Alzheimer's, Down syndrome may hold vital clues
  

  At first glance, Down syndrome (DS) and Alzheimer's disease (AD), two severe brain abnormalities, may seem to have little in common. Down syndrome is a hereditary disease, the source of which has long been recognized--a triplication of chromosome 21. By contrast, the overwhelming majority of Alzheim more

• Principles of limb regeneration in salamanders show link to mammals
  

  Scientists have long argued over which cells enable salamanders to grow back lost limbs. By tracking lineages and characterising individual cells, researchers could now show that connective tissue cells develop stem-cell-like properties and underlie the regeneration of legs. Among all four-legged an more

White papers Pathology

• Expression Analysis of ABC Transporters in Lung Cancer Cell Lines Using a RealTime ready qPCR Focus Panel
  

  The novel small molecule inhibitors are often substrates of ABC transporters which influence the pharmacokinetic parameters of the drug candidates and cause drug resistance of tumor cells. Therefore expression profiling of ABC transporter genes in ce more

• Altered Expression of Broad Range of Protease Genes in SH-SY5Y Neuroblastoma Cells after Bortezomib Exposure
  

  Neuroblastoma cell lines can be models for the responsiveness of neuroblastomas to chemotherapy-induced cell death as well as for the sensitivity of untransformed neuro-nal cells to toxic side-effects of chemotherapy. Both phenom-ena are relevant to more

Publications Pathology

• QnAs with Rafael Radi [QnAs]

  Rafael Radi has received numerous awards for his work on free radicals, oxidants, and reduction/oxidation pathways in biomedicine. During a long and fruitful career, he has characterized the formation and chemistry of peroxynitrite, including its role in mitochondrial dysfunction, pathology, and in more

• Differentiated human airway organoids to assess infectivity of emerging influenza virus [Microbiology]

  Influenza virus infection represents a major threat to public health worldwide. There is no biologically relevant, reproducible, and readily available in vitro model for predicting the infectivity of influenza viruses in humans. Based on the long-term expanding 3D human airway organoids, we develope more

• A molecular mechanism for choosing alcohol over an alternative reward

  “Only” about 10 to 15% of people exposed to alcohol develop alcohol-related problems. The behavioral repertoire of people confronted with opportunities to consume alcohol involves numerous choices between this drug reward and healthy alternatives. Augier et al. established a choice procedure that be more