Turning 'junk' DNA into gold

New protein targets for drug development against prostate cancer

19-Nov-2019 - Mining the rich uncharted territory of the genome or genetic material of a cancer cell has yielded gold for Princess Margaret scientists: new protein targets for drug development against prostate cancer. Using state-of-the-art, whole-genome sequencing technologies on prostate tumour samples, ...

Graphene nanoflakes: a new tool for precision medicine

20-Aug-2019 - Chemists funded by the SNSF have created a new compound for flexible drug delivery that specifically targets prostate cancer cells. Incorporating four different molecules, the compound prevents tumour cells from multiplying, can be detected by medical imaging and has staying power in the ...

How to quell a cytokine storm: New ways to dampen an overactive immune system

Penn Medicine, University of Leeds findings have implications for new drug targets for lupus, other autoimmune disorders

03-Jun-2019 - BRCA--the family of DNA-repair proteins associated with breast, ovarian, prostate, and pancreatic cancers--interacts with a multipart, molecular complex that is also responsible for regulating the immune system. When certain players in this pathway go awry, autoimmune disorders, like lupus, can ...

Scientists identify compounds in coffee which may inhibit prostate cancer

19-Mar-2019 - For the first time, scientists have identified compounds found in coffee which may inhibit the growth of prostate cancer. This is a pilot study, carried out on drug-resistant cancer cells in cell culture and in a mouse model; it has not yet been tested in humans. This work is presented at the ...

Prostate cancer – New computer model enables researchers to predict course of disease

18-Dec-2018 - How does a normal cell turn into a deadly cancer? Seeking an answer to this question, and working alongside other international working groups, researchers from Charité – Universitätsmedizin Berlin examined the tumor genomes of nearly 300 prostate cancer patients. Their findings describe the ways ...

Neutralizing reactive nitrogen molecules to enhance cancer immunotherapy

31-Oct-2018 - Immunotherapy -- harnessing T-cells to attack cancer cells in the body -- has given hope to patients who endure round after round of treatment, including chemotherapy, to little effect. For all of its promise, however, immunotherapy still benefits only a minority of patients -- a reality driving ...

Who won the Nobel Prize for Physiology or Medicine and for which research?

01-Oct-2018 - The Nobel Prize for Physiology or Medicine focuses on the research on cancer immunotherapies. Two pioneers in this field were awarded for their almost life-long research in this area. The laureates James P. Allison Born in 1948 the scientists worked at several famous and major cancer research ...

UCLA researchers develop mechanism for characterizing function of rare tumor cells

Findings could lead to more personalized treatments for people with cancer

20-Sep-2018 - Scientists have long known that circulating tumor cells, rare cancer cells that are released into the bloodstream, have the potential to provide vital information about a person's specific cancer. But until now, they have been unable to reliably access information on how these cells behave. UCLA ...

Blueprints for anti-cancer drugs discovered in bacterial genomes

14-Dec-2017 - Scientists on the Florida campus of The Scripps Research Institute (TSRI) who had previously discovered the prostate cancer-killing compound LNM E1 have now brought the family of LNM molecules even closer to clinical testing by "mining" the information stored in bacteria genomes. Their research ...

Recipharm and LIDDS establish industrial manufacturing capabilities

Manufacturing line for prostate cancer product set up

21-Jul-2017 - Recipharm and LIDDS have together set up a manufacturing line for LIDDS’ novel prostate cancer drug, Liproca®Depot, at Recipharm in Solna, Sweden. The manufacturing line is dedicated to the first product based on LIDDS’ innovative NanoZolid®technology. Clinical trial material has already been ...