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58 Current news about the topic dna replication

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How bacteria control their cell cycle

07-Jan-2020

Researchers at the Biozentrum of the University have demonstrated how bacteria coordinate cell division with the replication of their genetic material. In an interdisciplinary study they explain why the current concept of the bacterial cell cycle has to be rewritten. Each living cell grows and ...

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Evotec and venture capital consortium form "Breakpoint Therapeutics GmbH"

Early stage funding amounting to € 30 m

09-Jul-2019

Evotec SE announced the formation of Breakpoint Therapeutics GmbH, a spin-off company focusing on the development of Evotec’s DNA damage response (“DDR”) portfolio, comprising discovery-stage assets and drug targets that promise broad therapeutic application in a variety of cancers. Breakpoint ...

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Pathogens may evade immune response with metal-free enzyme required for DNA replication

23-Oct-2018

Some bacterial pathogens, including those that cause strep throat and pneumonia, are able to create the components necessary to replicate their DNA without the usually required metal ions. This process may allow infectious bacteria to replicate even when the host's immune system sequesters iron ...

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Key role found for enzymes in DNA replication and sensitivity to chemotherapeutic drugs

13-Aug-2018

During cell growth, cells copy their DNA through a process called DNA replication. For this process to be accurate, the genetic and epigenetic information must be copied flawlessly. In this regard, researchers led by Travis H. Stracker at the Institute for Research in Biomedicine (IRB Barcelona), ...

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Mutation 'hotspots' in DNA could lead to new insights on cancer risks

01-Aug-2018

New research from Indiana University has identified "hotspots" in DNA where the risk for genetic mutations is significantly elevated. These mutations arise because "typos" can occur as DNA replicates during cellular division. A recent analysis, which found that random mistakes in DNA play a large ...

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Timing is key for bacteria surviving antibiotics

04-Jul-2018

For bacteria facing a dose of antibiotics, timing might be the key to evading destruction. In a series of experiments, Princeton researchers found that cells that repaired DNA damaged by antibiotics before resuming growth had a much better chance of surviving treatment. When antibiotics hit a ...

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Biomarker helps identify 'window of opportunity' for cancer chemotherapy timing

11-Apr-2018

Angiogenesis, the formation of new blood vessels, is essential for tumor growth. A new study describes a vascular stabilization biomarker that can visualize blood vessel activity, thus optimizing the timing of anticancer therapies including anti-angiogenics. Combination therapy using angiogenesis ...

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How the most common DNA mutation happens

05-Feb-2018

Researchers describe how two normally mismatched bases in human DNA, guanine and thymine, are able to change shape in order to form an inconspicuous rung on the helical DNA "ladder." This allows them to survive by avoiding the body's natural defenses against genetic mutations. "When these two ...

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‘Hypermutators’ Drive Pathogenic Fungi to Evolve More Rapidly

28-Sep-2017

Mutations tend to get a bad rap, and deservedly so. A single defect in our DNA can strip us of our sight, thicken our lungs with mucus, prompt us to bleed to death, weaken our muscles or fill our organs with tumors. But in certain situations, a mutation can actually be a source of strength. For ...

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New 3-D imaging reveals how human cell nucleus organizes DNA and chromatin of its genome

31-Jul-2017

Sixty-four years ago, James Watson and Francis Crick described the now-iconic double helix structure of DNA. A team of researchers at the University of California San Diego School of Medicine and the Salk Institute for Biological Studies describe development and application of new electron ...

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