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12-Feb-2008 - Out of chaos, control: Cornell molecular biologists have discovered how a protein called PARP-1 binds to genes and regulates their expression across the human genome. Knowing where PARP-1 is located and how it works may allow scientists to target this protein to battle common diseases, such as ...
DNA damage in a new light
25-Apr-2007 - It has long been known that UV light can damage DNA, reducing its ability to replicate and interact with proteins, and often resulting in the development of skin cancers. However, not much is known about how the elasticity of DNA strands is altered upon exposure to UV light. Now a group of ...
13-Feb-2007 - An international multi-centre research effort, including Karolinska Institutet, has identified a new genetic defect as a potential heritable breast cancer susceptibility candidate. To some extent, prostate cancer also seems to be caused by the discovered PALB2 mutation. The two major familial ...
16-Nov-2006 - Proteins called H2AX act as "first aid" to DNA, among other roles. For the first time, scientists using the, according to The Jackson Laboratory, world's most powerful light microscope have seen how H2AX is distributed in the cell nucleus: in clusters, directing the first-aid repair after DNA ...
23-Oct-2006 - A new study by researchers from The Scripps Research Institute, Lawrence Berkeley National Laboratory, the Washington University School of Medicine, and the University of Maryland has provided a clearer picture of the final steps of a critical DNA repair process. When these repair processes go ...
Scientists show that oxidized nucleobases in human DNA are associated with "hotspots" of genetic recombination and polymorphism
02-May-2006 - Scientists from Kyushu University report in "Genome Research" how environmentally damaged DNA may contribute to human genetic diversity. They describe the co-occurrence of an aberrant nucleobase, called 8-oxoguanine (8-oxoG), with genomic regions enriched in meiotic recombination "hotspots" and ...
New Discovery Could Help Improve Some Forms of Chemotherapy
10-Apr-2006 - Scientists at The Scripps Research Institute and Lawrence Berkeley National Laboratory have determined the crystal structure of an enzyme called xeroderma pigmentosum group B (XPB) helicase, identifying several unexpected functions and helping to address important questions about the enzyme's ...
10-Mar-2006 - Can mobile genetic elements or transposons be used as genetic tools for gene discovery or for gene therapy? And how do they affect their host cell? These are questions which Dr. Zoltán Ivics and Dr. Zsuzsanna Izsvák from the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch in Germany ...
29-Aug-2005 - Scientists from the Flanders Interuniversity Institute for Biotechnology (VIB) have achieved a new breakthrough in cancer research. The researchers, connected to Ghent University, have discovered the function of an important mediator involved in suppressing the development of tumors. Using a ...
30-Jun-2005 - Premature aging syndromes often result from mutations in nuclear proteins involved in genomic integrity. For example Hutchinson-Gilford progerial syndrome (HGPS), a severe form of early-onset premature aging, is caused by truncation in the protein lamin A. Lamin A is a nuclear protein important ...
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