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2,896 Current news about the topic diseases

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Breaks in the genome

New method to improve the diagnosis of genetic diseases

28-Jul-2020

Breaks and rearrangements in the genome can lead to severe diseases, even if all genes remain intact. Hi-C, a method to map the three-dimensional structure of chromosomes, promises more reliable and accurate diagnoses of such defects, but is not used in the clinic yet. A team of researchers at ...

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GSK and CureVac announce strategic mRNA technology collaboration

Companies to collaborate on mRNA vaccine and monoclonal antibody research programmes in infectious diseases

21-Jul-2020

GlaxoSmithKline plc and CureVac announced the signing of a strategic collaboration agreement for the research, development, manufacturing and commercialisation of up to five mRNA-based vaccines and monoclonal antibodies (mAbs) targeting infectious disease pathogens. The collaboration complements ...

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Age-related impairments reversed in animal model

Belly fat as a source of chronic inflammation

08-Jul-2020

Frailty and immune decline are two main features of old age. Researchers from the University of Bern and the University Hospital Bern now demonstrate in an animal model that these two age-related impairments can be halted and even partially reversed using a novel cell-based therapeutic ...

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Low proteasome activity - short life span?

Ability to eliminate spent proteins influences brain aging and individual life span

23-Jun-2020

Aging is the main risk factor for dementia and Parkinson’s disease. As age progresses, toxic protein aggregates pile up in the brain and impair neuronal function. But why does that happen? An international team of scientists coordinated by the Leibniz Institute on Aging - Fritz Lipmann Institute ...

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Development of novel proteasome inhibitors for treating cancer, inflammatory and autoimmune disorders

Launch of Start-up QLi5 Therapeutics

18-Jun-2020

The Lead Discovery Center GmbH (LDC) and the South Korean drug development specialist Qurient have founded QLi5 Therapeutics GmbH, together with their partners, the Max Planck Society (MPG) and Nobel laureate Prof. Huber, emeritus director of the Max Planck Institute for Biochemistry. Dortmund ...

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How a microRNA protects vascular integrity

Hitherto unknown molecular function of a specific microRNA preserves integrity of the endothelium and reduces the risk of atherosclerosis

08-Jun-2020

Short RNA molecules known as microRNAs (miRNAs) play a vital role in the regulation of gene expression. Anomalies in miRNAs expression and function have been implicated in pathological processes, such as the development of chronic diseases like atherosclerosis. The regulatory functions of miRNAs ...

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New marine molecules with therapy potential against Alzheimer's disease

A promising but delicate therapeutic target

03-Jun-2020

An interdisciplinary research study of the University of Barcelona identified two potential candidates to treat Alzheimer's disease. These are two marine molecules, meridianine and lignarenone B, able to alter the activity of GSK3B activity, a protein associated with several neurodegenerative ...

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Riesling for the immune system?

How alcohol in moderation has a positive effect on impaired immune reactions

15-May-2020

We all know that excessive consumption of alcohol is bad for our health. Moderate quantities of alcohol, however, can be beneficial to our health in some circumstances. In a paper published in Nature, a team of researchers from FAU shows that alcohol modifies the immune system in a very specific ...

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Platelets exacerbate immune response

Clotting cells are also an important regulator of inflammation

14-May-2020

Platelets not only play a key role in blood clotting, but can also significantly intensify inflammatory processes. This is shown by a new study carried out by scientists from the University of Bonn together with colleagues from Sao Paulo (Brazil). In the medium term, the results could open up new ...

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Unexpectedly potent protein droplets

Researchers discover new pathomechanism of hereditary diseases in cell condensates

11-May-2020

Repeats of individual building blocks within proteins are the cause of many hereditary diseases, but how such repeats actually cause disease is still largely unknown. Researchers in Berlin investigated how repeat elongations lead to the disease synpolydactyly, and have found that the attractive ...

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