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19 Current news about the topic cell nucleusrss
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Scientists use mass spectrometry to determine the absolute copy number of nuclear proteins and histone marks
Currently, most if not all of the proteins that are required for constructing a multicellular organism are known. However, it is largely unclear how many copies of each protein species are present and needed to permit an animal to develop into a complete organism. Researchers at the Max Planck ...
Researchers discover the mechanism that prevents damage caused by shortened proteins
The cell contains transcripts of the genetic material, which migrate from the cell nucleus to another part of the cell. This movement protects the genetic transcripts from the recruitment of “spliceosomes”. If this protection does not happen, the entire cell is in danger: meaning that cancer and ...
Induced pluripotent stem cells can turn into any type of cell in the body or remain in their original form. In the current edition of Molecular Cell, scientists from the Helmholtz Zentrum München describe how cells “decide” which of these two directions to take. During their research, they ...
Mobile cells move around obstacles in dense tissue by selecting for larger pore sizes
How do mobile cell types like leukocytes or metastatic cancer cells reach their place of action during immune surveillance or cancer dissemination, respectively? The research group around Michael Sixt at IST Austria has now shown that leukocytes use their nucleus as a ruler to screen their ...
Protein production efficiency can be predicted by gene sequence
Today, thousands of databases with biological data are publicly available. They include data on gene and protein sequences and detailed measurements of different cellular parameters, such as the exact quantities of all proteins produced and degraded by a given cell in various experimental ...
Method giving complete spatiotemporal control and treads DNA lightly
A major obstacle to in-cell genome editing is, well, the cell itself.“Human cells don’t like to take in stuff,” explained UC Santa Barbara’s Norbert Reich, a professor in the Department of Chemistry and Biochemistry. The human cell has evolved a “trash disposal” mechanism that isolates and breaks ...
Probably relevant to other cellular transport as well
The manner in which some viruses inject their DNA into bacteria or other types of cells, appears to be much simpler than scientists had previously thought. Rather than using molecular engines or complicated mechanisms, viruses let simple physics do the work for them. This is a recent finding by ...
New insights into the development of the vascular system
New insights into the development of the vascular system: researchers in the team of Dr Carmen Ruiz de Almodóvar of the Heidelberg University Biochemistry Center have discovered a crucial biological step that regulates the formation of blood vessels. They were able to show that the proteins YAP ...
The presence of DNA in mammalian cell cytoplasm triggers an immune response by binding to a dimeric enzyme, which inserts between DNA double helices to form the “rungs” of a ladder-like structure, as an LMU team has now shown. In higher organisms, the genetic material is normally confined to the ...
G protein-coupled receptors are the key target of a large number of drugs. Würzburg scientists have now been able to show more precisely how these receptors act in the cell interior. The human genome encodes hundreds of G protein-coupled receptors (GPCRs). These form the largest group of ...