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Making systems robust: Artificial genetic regulatory network introduced into living cell for the first time

Improving biotech and therapies

24-Jun-2019

Both nature and technology rely on integral feedback mechanisms to ensure that systems resist external perturbations. ETH researchers have now used synthetic biology to design a new mechanism of this sort from scratch. For the first time, they have introduced it into a living cell as an ...

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Efficiently producing fatty acids and biofuels from glucose

24-Jun-2019

Researchers have presented a new strategy for efficiently producing fatty acids and biofuels that can transform glucose and oleaginous microorganisms into microbial diesel fuel, with one-step direct fermentative production. The newly developed strain, created by Professor Sang Yup Lee and his ...

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Cancer control: Structure of important transport protein solved

Discovery of promising binding site

21-Jun-2019

For the first time, Bernese researchers have been able to solve the structure of a transport protein and thus to describe the functional mechanism that plays a significant role in the survival of cancer cells. This is an important step towards developing effective inhibitors and fight tumor ...

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How bacteria protect themselves from plasma treatment

21-Jun-2019

Plasmas are applied in the treatment of wounds to combat pathogens that are resistant against antibiotics. But bacteria know how to defend themselves. Considering the ever-growing percentage of bacteria that are resistant to antibiotics, interest in medical use of plasma is increasing. In ...

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European Patent Office honours exceptional inventors with European Inventor Award 2019

21-Jun-2019

The European Patent Office (EPO) honoured exceptional inventors from Austria, France, Japan, the Netherlands and Spain with the European Inventor Award 2019 at a ceremony in Vienna. The laureates are recognised for their outstanding achievements in plastic recycling, cancer diagnostics, ...

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Cell Division at High Speed

When two proteins work together, this worsens the prognosis for lung cancer patients

20-Jun-2019

In malignant tumours, the cells usually proliferate quickly and uncontrollably. A research team from the Biocenter of Julius-Maximilians-Universität (JMU) Würzburg in Bavaria, Germany, has discovered that two important regulators of cell division can interact in this process. If this is the case, ...

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Tox "exhausts" immune cells

Molecular switch for reduced immune cell function discovered

19-Jun-2019

Tumors and certain viral infections pose a challenge to the human body which the immune system typically fails to hand. In these diseases it switches to hypofunctional state that prevent adequate protection. A research team from the Technical University of Munich (TUM) has achieved a major ...

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Redundancies in T cells

19-Jun-2019

Researchers at ETH Zurich have discovered redundancies in the biochemical signalling pathways of immune cells. This finding has important implications for advances in cancer immunotherapy, among other areas. Oncologists have had great success with cancer immunotherapy in recent years, especially ...

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Drug resistance: Preventing drugs from being transported

18-Jun-2019

Certain membrane proteins specialise in transporting molecules out of cells – a problem for the efficacy of cancer medication and antibiotics. An international research team has investigated the transport mechanism of a bacterial membrane protein using an artificially produced antibody fragment. ...

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Pharmaceutical Production with Reduced Waste

Platform technology for producing cephalosporin antibiotics

18-Jun-2019

Antibiotics save countless human lives – modern medicine without them is unimaginable. The largest proportion by volume of industrially produced antibiotics today are cephalosporins, structural variants of the first antibiotic, penicillin. Unfortunately, their production generates a considerable ...

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