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01-Jul-2009 - Melanoma is the most serious form of skin cancer, diagnosed in more than 50,000 new patients in the United States annually. While the rate of incidences continues to rise, survival rate has not improved and the race is on to find the genetic and cellular changes driving melanoma and to devise ...
01-Oct-2007 - A study by Yale researchers offers a new view of what causes the greatest genetic variability among individuals - suggesting that it is due less to single point mutations than to the presence of structural changes that cause extended segments of the human genome to be missing, rearranged or ...
08-Nov-2006 - Alnylam Pharmaceuticals, Inc. announced publication of data demonstrating that an RNAi therapeutic can silence angiopoietin 2 (Ang2), a key mediator in acute lung injury. In a paper published in Nature Medicine, scientists from Yale University and Alnylam demonstrated inhibition of acute lung ...
02-Oct-2006 - A Yale School of Medicine study shows for the first time that a high level of testosterone, such as that caused by the use of steroids to increase muscle mass or for replacement therapy, can lead to a catastrophic loss of brain cells. Taking large doses of androgens, or steroids, is known to ...
08-Jun-2006 - In Salmonella, structural changes to the molecular infection apparatus also signal an end to its further assembly. The mechanistic details of this sophisticated feedback system, which takes place at molecular level, have now been published. Better understanding of how this pathogen¹s needle-like ...
04-Jan-2006 - Carbonated soft drink consumption was previously suggested to be linked to the 350 percent increase of adenocarcinoma of the esophagus since the mid-1970s, but researchers at Yale School of Medicine report that the link is unfounded and that there may, in fact, be a decreased risk of this cancer ...
16-Aug-2005 - A collaborative project between American and Chinese researchers developed a way to study the function of genes in mice and man by using a moveable genetic element from moths, according to a report in the journal Cell. "We know how many genes are in the mammalian genome, but that does not tell ...
06-Jun-2005 - A report by Yale scientists in the journal Cell sheds new light on how the protein Ro, a major autoantigen in patients with autoimmune disease, recognizes misfolded RNAs, creating a RNA quality control system for cells. The quality control process in the cell has been well-studied for the DNA and ...
Gene ensures programmed cell suicide does not go unchecked
24-May-2005 - Researchers recently discovered a gene essential to one of the plant kingdom's key immune responses--programmed cell death (PCD). Plants use PCD to create a protective zone of dead cells around the infection site to prevent the invading pathogen from spreading. But how the plants keep from ...
08-Mar-2005 - Impaired function of a receptor that regulates release of a mood elevating hormone in the brain may be responsible for causing depression, anxiety and cardiovascular disorders, according to a Yale study in Pharmacogenetics and Genomics. The genetic variant that causes this malfunction is nearly ...
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