Genome architecture caught in motion

12-Oct-2017 - Researchers at The Wistar Institute have uncovered new aspects of the three-dimensional organization of the genome, specifically how the genetic material is compacted and de-compacted in a timely fashion during the different phases of the cell cycle. "We are just starting to appreciate that the ...

Scientists overcome missing data to demonstrate ART effectiveness in HIV-infected infants

26-Jan-2016 - Recent clinical trials conducted in South Africa have established that babies born with HIV should be treated with antiretroviral therapy (ART) as early as possible, since earlier treatment significantly decreases their mortality and morbidity rates. However, scientists were unsure whether ...

Traitorous immune cells promote sudden ovarian cancer progression

First model of aggressive ovarian cancer demonstrates immune system's active role in tumor progression

22-Feb-2012 - Aggressive ovarian tumors begin as malignant cells kept in check by the immune system until, suddenly and unpredictably, they explode into metastatic cancer. New findings from scientists at The Wistar Institute demonstrate that ovarian tumors don't necessarily break "free" of the immune system, ...

Sigma-Aldrich Welcomes the University of Edinburgh to the RNAi Partnership Program

06-Oct-2006 - Sigma-Aldrich, a member of The RNAi Consortium (TRC) proudly welcomes the University of Edinburgh to the RNAi Partnership Program. As the newest member of the RNAi Partnership Program, the University of Edinburgh gains access to cutting-edge products in Sigma-Aldrich's functional genomics ...

Study Identifies Molecular Complex Vital to Creation of miRNAs

Possible Links to DiGeorge Syndrome, Schizophrenia Also Seen

19-Nov-2004 - Tiny bits of short-lived genetic material called microRNAs, or miRNAs, have attracted enormous interest from scientists since their discovery in humans only a few years ago. Viewed most broadly, they appear to play significant roles in controlling gene expression and development in many different ...