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'Breathing' enzymes in fast motion

Researchers watch work of an enzyme in unprecedented detail

23-Sep-2019

Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Potsdam (both in Germany) and the University of Toronto (Canada) have pieced ...

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Researchers create nano-bot to probe inside human cells

15-Mar-2019

University of Toronto Engineering researchers have built a set of magnetic 'tweezers' that can position a nano-scale bead inside a human cell in three dimensions with unprecedented precision. The nano-bot has already been used to study the properties of cancer cells, and could point the way ...

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Unraveling a genetic network linked to autism

06-Nov-2018

Donnelly Centre researchers have uncovered a genetic network linked to autism. The findings will facilitate developing new therapies for this common neurological disorder. As part of a collaborative research program focusing on autism led by Benjamin Blencowe, a professor in the University of ...

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A DNA 'shield' with crucial roles in normal cell division

20-Jul-2018

In immune cells, this is crucial to make antibodies In cancer, mutations in complex could lead to resistance to BRCA-targeting PARP inhibitor drugs or platinum chemotherapies Scientists have made a major discovery about how cells repair broken strands of DNA that could have huge implications for ...

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Memory part of the brain may also hold clues for anxiety and depression

17-Apr-2018

The hippocampus is an area of the brain commonly linked with memory and dementia. But new U of T Scarborough research finds that it may also yield important clues about a range of mental health illnesses including addiction, anxiety and depression. The research, authored by a team of ...

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NMR technique offers 'molecular window' into living organisms

04-May-2017

A novel technique developed by University of Toronto Scarborough researchers can for the first time get a high-resolution profile of which molecules are present inside a living organism. "In a way we've developed this molecular window that can look inside a living system and extract a full ...

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A new way to discover structures of membrane proteins

08-Feb-2017

University of Toronto scientists have discovered a better way to extract proteins from the membranes that encase them, making it easier to study how cells communicate with each other to create human health and disease. Scientists are very interested in understanding how membrane proteins work and ...

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Certainty in complex scientific research an unachievable goal

03-Feb-2017

A University of Toronto study on uncertainty in scientific research could shed light on anomalies that arose in early attempts to discover the Higgs boson and even how polls failed to predict the outcome of Donald Trump winning the U.S. presidential election. The study suggests that research in ...

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First complete interactome map of human receptor tyrosine kinases and phosphatases

09-Jan-2017

In 2011, Igor Stagljar, a professor in the University of Toronto's Donnelly Centre, came across a study that genetically linked two genes in the cell to a hard-to-treat (triple negative) breast cancer. It was not clear how the proteins encoded by these genes worked, but Stagljar had a unique way ...

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Skin cells 'crawl' together

Healing wounds treated with unique hydrogel layer

15-Dec-2016

Time may not heal all wounds, but a proprietary mix of peptides and gel developed by U of T Engineering researchers heals most. A team led by Professor Milica Radisic has demonstrated for the first time that their peptide-hydrogel biomaterial prompts skin cells to "crawl" toward one another, ...

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