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Formation of quadruple helix DNA tracked in live human cells for the first time

The biology of DNA must be rethink


The formation of four-stranded DNA has been tracked in living human cells, allowing scientists to see how it works, and its possible role in cancer. DNA usually forms the classic double helix shape discovered in 1953 - two strands wound around each other. Several other structures have been formed ...


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Protein complex prevents toxic aggregation of proteins


A protein complex within the cell has been found to play a key role in preventing the toxicity of proteins which build up amyloid plaques and can lead to neurodegenerative disorders such as Alzheimer’s and Huntington’s disease. Researchers from the Universities of Konstanz (Germany), Leeds (UK) ...


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Libraries for Proteins

Dynamic combinatorial libraries generated from hydrazone-functionalized surface mimetics


Combinatorial libraries are a key component of the chemist's toolkit for ligand screening. Dynamic combinatorial libraries add a new dimension by interlinking synthesis and screening. Now, British scientists have developed a dynamic combinatorial library for the screening of supramolecular ligand ...


How old antibiotic compounds could become tomorrow's life-saving drugs


As the fight against drug-resistant infections continues, University of Leeds scientists are looking back at previously discarded chemical compounds, to see if any could be developed for new antibiotics. In the heyday of antibiotic development in the mid-20th century many different chemical ...


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A novel textile material that keeps itself germ-free


Scientists have developed a novel weapon in the battle against deadly hospital-acquired infections - a textile that disinfects itself. And independent tests show it can reduce bacteria levels by more than 90 per cent. By incorporating the specially-engineered textile in a device designed to be ...


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Better tools to study the processes of life


Scientists have developed a new biological tool for examining molecules - the building blocks of life - which they say could provide new insights and other benefits such as reducing the numbers of animals used in experiments. The University of Leeds in collaboration with Avacta Life Sciences, a ...


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Supercoiled DNA is far more dynamic than the 'Watson-Crick' double helix


Researchers have imaged in unprecedented detail the three-dimensional structure of supercoiled DNA, revealing that its shape is much more dynamic than the well-known double helix. Various DNA shapes, including figure-8s, were imaged using a powerful microscopy technique by researchers at the ...


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Gold nanotubes launch a three-pronged attack on cancer cells


Scientists have shown that gold nanotubes have many applications in fighting cancer: internal nanoprobes for high-resolution imaging; drug delivery vehicles; and agents for destroying cancer cells. The study, published in the journal Advanced Functional Materials, details the first successful ...


'Office life' of bacteria may be their weak spot


Scientists at the University of Leeds think we may be able to drown deadly bacteria in their own paperwork. A research team in the University's Astbury Centre for Structural Molecular Biology has identified for the first time how the "paper shredder" that keeps the bacteria E. coli on top of its ...


Anti-angina drug shows protective effects from carbon monoxide


An international research team, led from the University of Leeds, has found that a common anti-angina drug could help protect the heart against carbon monoxide poisoning.Animal studies have shown that the anti-angina drug ranolazine can significantly reduce the number of deaths from arrhythmias – ...


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