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7 Current news of St. Jude Children's Research Hospital

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Gene therapy improves immunity in babies with 'bubble boy' disease

11-Dec-2017 - Early evidence suggests that gene therapy developed at St. Jude Children's Research Hospital will lead to broad protection for infants with the devastating immune disorder X-linked severe combined immunodeficiency disorder. Preliminary results from the ongoing, multicenter study were included in ...

antibodies B cells blood stem cells +9
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Allergies? Exhausted regulatory T cells may play a role

28-Aug-2017 - Researchers have evidence that the specialized T cells responsible for maintaining a balanced immune response are vulnerable to exhaustion that disrupts normal functioning and may even contribute to allergic reactions. St. Jude Children's Research Hospital scientists led the study. The report is ...

allergic reactions allergies asthma +15

Rescue protein gives doomed cells a stay of 'execution'

11-Apr-2017 - A research team led by St. Jude Children's Research Hospital immunologists has discovered how a set of proteins delays the "executioner" machinery that kills damaged or infected cells in a process called necroptosis. The scientists believe the finding may have wide clinical implications if ...

amyotrophic lateral sclerosis brain cells cancer cells +10
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Loss of essential protein in the choroid plexus epithelium linked to hydrocephalus

24-Jun-2016 - A team led by researchers at St. Jude Children's Research Hospital report that mice lacking the protein Alix develop hydrocephalus or "water on the brain." Alix ensures that epithelial cells of the choroid plexus are oriented correctly with respect to one another to prevent compromise of the ...

cerebrospinal fluid epithelial cells hydrocephalus +1

Pharmacogenomics study finds rare gene variants critical for personalized drug treatment

06-Dec-2011 - The use of genetic tests to predict a patient's response to drugs is increasingly important in the development of personalized medicine. But genetic tests often only look for the most common gene variants. In a pharmacogenomics study published in Genome Research, researchers have characterized ...

acute lymphoblastic leukemia autoimmune diseases cancer +4

Gene fusion mechanisms offer new clues to origin of pediatric brain tumors

10-Mar-2011 - A detailed analysis of gene fusions present at high frequency in the most common pediatric brain tumors has been performed for the first time in a study published in Genome Research, shedding new light on how these genomic rearrangements form in the early stages of cancer. Genomic rearrangements, ...

brain tumors genomics

Researchers identify a molecular switch that controls neuronal migration in the developing brain

30-Nov-2010 - St. Jude Children's Research Hospital investigators have identified key components of a signaling pathway that controls the departure of neurons from the brain niche where they form and allows these cells to start migrating to their final destination. Defects in this system affect the ...

adhesion brain development brain tumors +5