Biomarker predicts severity of Covid-19 infection early on

High expression of the fitness gene hFwe-Lose in the lung reliably predicts severe progression

28-Oct-2021 - Scientists of an international research team with participation of the Max Planck Institute for Heart and Lung Research in Bad Nauheim have identified a biomarker with the gene isoform hFwe-Lose, which indicates the "fitness degree" of lung epithelial cells. In the future, this can be used to ...

Genetic defects without consequences

mRNA of defective genes pushes compensation mechanism

15-Apr-2019 - Many diseases are caused by genetic defects. However, their severity can vary among individual patients, so that even mild forms can occur. Scientists at the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now decrypted a molecular mechanism responsible for this phenomenon. ...

Cancer diagnosis with a breath test

A new test for the early detection of lung cancer measures tiny changes in the composition of the breath

21-Apr-2017 - “Inhale deeply ... and exhale.” This is what a test for lung cancer could be like in future. Scientists at the Max Planck Institute for Heart and Lung Research in Bad Nauheim have developed a method that can detect the disease at an early stage. To this effect, they investigated the presence of ...

Finished heart switches stem cells off

Transcription factor Ajuba regulates stem cell activity in the heart during embryonic development

20-Jul-2012 - It is not unusual for babies to be born with congenital heart defects. This is because the development of the heart in the embryo is a process which is not only extremely complex, but also error-prone. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now ...

Preventing heart problems while keeping a cool head

28-Jul-2010 - Cholesterol influences the health of our hearts and blood vessels. Conventional treatment attempts to reduce the level of "bad" cholesterol, LDL cholesterol, in the blood plasma. The opposite approach, which involves increasing the concentration of "good" HDL cholesterol using nicotinic acid, has ...