TET proteins drive early neurogenesis

12-Dec-2016 - The fate of stem cells is determined by series of choices that sequentially narrow their available options until stem cells' offspring have found their station and purpose in the body. Their decisions are guided in part by TET proteins rewriting the epigenome, the regulatory layer of chemical ...

New sickle cell anemia therapy advances to Phase II clinical trials

13-Jun-2013 - Seeking to improve the lives of sickle cell anemia sufferers around the world, researchers from the La Jolla Institute for Allergy and Immunology, the Dana-Farber/Children's Hospital Cancer Center in Boston and the BloodCenter of Wisconsin in Milwaukee and others are preparing to launch Phase II ...

La Jolla Institute's surprising finding could alter the face of dengue vaccine development

New data on T cells' protective role suggests need for new approach to dengue vaccine design

16-Apr-2013 - As efforts to create a strong and effective vaccine for the dreaded dengue virus continue to hit snags, a new study from researchers at the La Jolla Institute for Allergy & Immunology offers surprising evidence that suggests the need for a revamped approach to dengue vaccine design. The finding ...

A vaccine for heart disease?

La Jolla Institute discovery points up this possibility

16-Aug-2012 - Most people probably know that heart disease remains the nation's No. 1 killer. But what many may be surprised to learn is that cholesterol has a major accomplice in causing dangerous arterial plaque buildup that can trigger a heart attack. The culprit? Inflammatory cells produced by the immune ...

La Jolla Institute finds previous seasonal flu infections may provide some level of H1N1 immunity

18-Nov-2009 - Researchers at the La Jolla Institute for Allergy & Immunology have found that previous influenza infections may provide at least some level of immunity to the H1N1 "swine" flu. "The question we asked was, "Is the swine flu more like the seasonal flu or like a totally new strain of influenza ...