Solved protein structure holds key to much-needed therapies for metabolic disorder

17-Feb-2016 - Phenylketonuria, also known as PKU, is the most common inherited disease affecting amino acid metabolism. Children are tested for PKU at birth, and babies diagnosed with the disease must adhere to a highly restricted diet to prevent permanent intellectual impairment. Recent advances reveal a ...

Protein tied to cancer drug resistance in mice

14-Dec-2012 - Blocking a specific protein renders tumors more vulnerable to treatment in mice, suggesting new therapies could eventually achieve the same in humans, according to new research from Fox Chase Cancer Center. The protein in question is a type of ATP-binding cassette drug efflux pumps, known more ...

Horizon Discovery and Fox Chase Cancer Center announce collaboration to apply rAAV gene targeting in mouse embryonic stem cells and research into EGFR-therapy resistance.

Collaboration will establish a new Center Of Excellence in Mammalian Gene Editing

27-Apr-2011 - Horizon Discovery has announced that it has entered into a three-year collaboration with the Fox Chase Cancer Center (Fox Chase). The focus of the collaboration is to apply rAAV gene targeting in mouse embryonic stem (ES) cells, and for the discovery of genes involved in resistance to ...

New treatment regimen shown effective against advanced ovarian cancer

07-Jun-2010 - Newly reported results from a major clinical trial show that adding bevacizumab (Avastin) to standard frontline chemotherapy for women with advanced ovarian cancer and then continuing a maintenance dose of the drug afterwards significantly extends progression-free survival. Women receiving the ...

Engineered antibodies directed against a promising therapeutic target on ovarian cancer cells

20-Apr-2010 - Stealthy and stubborn, ovarian cancer is a particularly vexing malignancy, difficult to diagnose in early stages and difficult to treat once it progresses further. However, research at Fox Chase Cancer Center is now focusing on one of the most promising new approaches to dealing with the ...

Enzyme inhibitor takes an unexpected approach toward blocking cancer-promoting protein

09-Sep-2009 - Scientists at Fox Chase Cancer Center have discovered a unique method of attack that may be used to inhibit signaling enzymes called kinases, which often have a role in sustaining drug-resistant cancerous cells. They have confirmed that IPA-3, a small molecular inhibitor of a kinase called PAK1, ...

Lexicon Pharmaceuticals and Fox Chase Publish Findings on Immune Deficiency

12-Jun-2007 - Lexicon Pharmaceuticals, Inc. announced the publication of new findings from a joint research project with scientists at Fox Chase Cancer Center in Philadelphia, PA. Together with David L. Wiest, Ph.D., Lexicon researchers have discovered a novel role for ribosomal protein L22 (Rpl22) in the ...

OncoMethylome Science licenses gene methylation technology from Fox Chase Cancer Center to detect ovarian and kidney cancer

24-Jun-2005 - OncoMethylome Sciences announced that it has signed an exclusive licensing agreement with the Fox Chase Cancer Center, Philadelphia, Pa., for intellectual property describing the use of Methylation Specific PCR (MSP) technology and a panel of genes for the early detection of ovarian and kidney ...