Specificity by Ring Size
Bicyclic Peptides with Optimized Ring Size Inhibit Human Plasma Kallikrein and its Orthologs While Sparing Paralogous Proteases
17-Apr-2012 -
New drug candidates require testing in animal models prior to approval for clinical use. A recently developed antagonist based on a bicyclic peptide inhibited the human serine protease plasma kallikrein potently and selectively. However, the inhibitor was ‘too’ selective, not inhibiting murine ...
bicyclic peptides
inhibitors
peptides
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