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29 Current news of ecole-polytechnique-fdrale-de-lausanne

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Designing vaccines from artificial proteins

De novo protein design enables the precise induction of RSV-neutralizing antibodies

18-May-2020

Vaccines are one of the most effective interventions to prevent the spreading of infectious diseases. They trigger the immune system to produce antibodies that protect us against infection. However, we still lack efficacious vaccines for many important pathogens, like the flu or dengue fever. ...

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Emergence of calorie burning fat cells

A new approach to treating overweight and obesity

10-Jan-2020

1.9 billion people in the world are overweight. Of these, 650 million people are obese, which increases the risk of secondary diseases such as high blood pressure or cancer. Professor Martin Klingenspor and his team at the Technical University of Munich (TUM) examine how our fat metabolism ...

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Predicting a protein's behavior from its appearance

11-Dec-2019

Proteins are the building blocks of life and play a key role in all biological processes. Understanding how they interact with their environment is therefore vital to developing effective therapeutics and the foundation for designing artificial cells. Researchers at the Laboratory of Protein ...

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Six fingers per hand

A congenital additional finger brings motor advantages

05-Jun-2019

Polydactyly is the extraordinary condition of someone being born with more than five fingers or toes. In a case study published in Nature Communications, researchers from the University of Freiburg, Imperial College London, the University Hospital of Lausanne, and EPFL have for the first time ...

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Chirality in 'real-time'

Circular dichroism in the deep ultraviolet

11-Jan-2019

In nature, certain molecules with the same chemical composition, can exist in two different shapes that are mirrors images of each other, much like our hands. This property is known as "chirality" and molecules with different chirality are called enantiomers. Enantiomers can exhibit entirely ...

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Tumors backfire on chemotherapy

03-Jan-2019

Some patients with breast cancer receive chemotherapy before the tumor is removed with surgery. This approach, called 'neoadjuvant' therapy, helps to reduce the size of the tumor to facilitate breast-conserving surgery, and can even eradicate the tumor, leaving few or no cancerous cells for the ...

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Double-bridged peptides bind any disease target

03-May-2018

Peptides are short chains of amino acids that can bind to proteins and change their function. They show high binding affinity, low toxicity, and are easy to synthesize, all of which makes peptides ideal for use in drug development, and many naturally occurring peptides such as insulin, oxytocin, ...

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Cell senescence is regulated by innate DNA sensing

02-Aug-2017

Cells in the body or in cultures eventually stop replicating. This phenomenon is called "senescence" and is triggered by shortening of telomeres, oxidative stress or genetic damage to the cells, either acute or simply due to the cell growing "old". Understanding the causes and impact of ...

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A new ligand extends the half-life of peptide drugs from minutes to days

18-Jul-2017

Peptides are biological molecules, made up of short sequences of amino acids. Because they are easy to synthesize, show low toxicity and high efficiency, peptides such as insulin and other hormones can be used as drugs. But peptides are quickly cleared by the kidneys, which means that we can only ...

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Targeting blood vessels to improve cancer immunotherapy

18-Apr-2017

EPFL scientists have improved the efficacy of cancer immunotherapy by blocking two proteins that regulate the growth of tumor blood vessels. Cancer immunotherapy aims to enhance or restore the ability of the patient's immune system - namely T cells - to recognize and attack cancer. But tumors use ...

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