Common household chemicals pose new threat to brain health

Research shows chemicals in countless household items harm specialized cells in the brain

03-Apr-2024 - A team of researchers from theCase Western Reserve University School of Medicinehas provided fresh insight into the dangers some common household chemicals pose to brain health. They suggest that chemicals found in a wide range of items, from furniture to hair products, may be linked to ...

A human brain model in a petri dish?

Bioethics of brain organoids to be explored

19-Oct-2018 - Research scientists around the world are now able to investigate the structural, cellular, and developmental intricacies of the human brain using bioengineered stem cell-based models called organoids. But the ethics to help guide researchers and regulators lag behind the technological capability ...

A swallowable test to detect pre-cancerous Barrett's esophagus

19-Jan-2018 - Investigators at Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center have developed a simple, swallowable test for early detection of Barrett's esophagus that offers promise for preventing deaths from esophageal adenocarcinoma. Barrett's esophagus ...

New antifungal provides hope in fight against superbugs

16-Jan-2018 - Microscopic yeast have been wreaking havoc in hospitals around the world--creeping into catheters, ventilator tubes, and IV lines--and causing deadly invasive infection. One culprit species, Candida auris, is resistant to many antifungals, meaning once a person is infected, there are limited ...

Zooming in on protein to prevent kidney stones

Researchers use Nobel prize-winning technology to see vital kidney protein for the first time

04-Jan-2018 - Researchers have applied Nobel prize-winning microscope technology to uncover an ion channel structure that could lead to new treatments for kidney stones. In a recent study published in Nature Structural and Molecular Biology, researchers revealed atomic-level details of the protein that serves ...

Computer program finds new uses for old drugs

20-Nov-2017 - Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine have developed a computer program to find new indications for old drugs. The computer program, called DrugPredict, matches existing data about FDA-approved drugs to diseases, and predicts ...

Immune cells help rebuild damaged nerves

26-Oct-2017 - Immune cells are normally associated with fighting infection but in a new study, scientists have discovered how they also help the nervous system clear debris, clearing the way for nerve regeneration after injury. Researchers from Case Western Reserve University School of Medicine showed certain ...

Long, mysterious strips of RNA contribute to low sperm count

29-Aug-2017 - "Infertility affects 10 to 15 percent of couples in the United States, with the vast majority of cases due to unknown causes. Approximately 40 percent of these cases are due to male infertility," said senior author Khalil. Khalil and colleagues have been working to understand genetic mechanisms ...

Gene-delivery system prevents vision loss from inherited eye disease

12-May-2017 - Researchers at Case Western Reserve University have developed gene-carrying nanoparticles that home in on target cells and prevent vision loss in mice with a human form of Leber congenital amaurosis. The condition is one of the most common causes of blindness in children, according to the ...

Newly discovered chemical reaction in eye may improve vision

07-Apr-2017 - A light-sensing pigment found in everything from bacteria to vertebrates can be biochemically manipulated to reset itself, an important therapeutic advantage, according to new research out of Case Western Reserve University School of Medicine. In a study researchers successfully used a modified ...