Non-small cell lung cancers can be sorted in clusters by endocytic changes

15-Dec-2015 - In the Age of Personalized Medicine, we've learned that one size doesn't fit all, least of all in cancer. Cancer is a disease of your cells, and sorting out your cancer from all others is a daunting challenge but one that cancer cell biologists are furiously pursuing. They are examining every ...

From slowdown to shutdown

US leadership in biomedical research takes a blow, says ASCB

10-Oct-2013 - A senior researcher who can't get an answer from a shutdown NIH about a proposed clinical trial on a neurodegenerative disease, a Nobel Prize-winning scientist who fears that a generation of innovators will be lost, and a young investigator wearied at the lab by endless funding cuts and ...

Human cells build protein cages to trap invading Shigella

06-Dec-2011 - In research on the never-ending war between pathogen and host, scientists at the Pasteur Institute in Paris have discovered a novel defensive weapon, a cytoskeletal protein called septin, that humans cells deploy to cage the invading Shigella bacteria that cause potentially fatal human diarrhea, ...

Deleting ghrelin receptor, but not ghrelin, turns up fat-burning thermostat

16-Dec-2010 - Deleting the receptor, not the protein ghrelin itself, turns up the body's fat-burning thermostat, giving aging mice an exothermic boost toward a svelte physique, researchers reported at the American Society of Cell Biology's 50th Annual Meeting in Philadelphia. The protein's receptor, growth ...

Blocking molecular pathway with whimsical name possible therapeutic target for pancreatic cancer

18-Dec-2008 - A possible new therapeutic target for pancreatic cancer, the most lethal form of human cancer, has been identified in the proteins whose DNA recipe comes from gene, "Seven-In-Absentia," according to researchers at the American Society for Cell Biology (ASCB) 48th Annual Meeting in San ...