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Merck Licenses CRISPR Gene-Editing Technology to Evotec

License to accelerate research, enable testing and development of new drugs

13-Nov-2019

Merck announced that it has signed a license agreement providing Evotec SE access to Merck’s foundational CRISPR intellectual property. Evotec, an international biotechnology company headquartered in Hamburg, Germany, will use Merck’s CRISPR genome-editing technology to create edited cell lines ...

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Antibiotics: New substances break bacterial resistance

13-Nov-2019

Researchers at the Martin Luther University Halle-Wittenberg (MLU) have developed a new, promising class of active ingredients against resistant bacteria. In initial tests in cell cultures and insects, the substances were at least as effective as common antibiotics. The new compounds target a ...

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Small RNAs link immune system and brain cells

Sex-specific processes in schizophrenia and bipolar disorder

13-Nov-2019

Recent studies have found a high genetic similarity of the psychiatric diseases schizophrenia and bipolar disorder, whose disease-specific changes in brain cells show an overlap of more than 70 percent. These changes affect gene expression, i.e., transcription of genes for the purpose of ...

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Synapses in 3D

Scientists develop new method to map brain structures

12-Nov-2019

Our brain consists of countless nerve cells that transmit signals from one cell to the next. The connections between these cells, the synapses, provide a key to understanding how our memory works. An American research team in collaboration with Rainer Heintzmann from the Leibniz Institute of ...

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Deciphering how the brain controls our weight

Jens Brüning receives 2019 Heinrich Wieland Prize

12-Nov-2019

Professor Jens Brüning, Director at the Max Planck Institute for Metabolism Research in Cologne, Germany, has been honoured with the 2019 Heinrich Wieland Prize for his pioneering work on how the brain regulates the uptake, storage, and use of energy in the body. He has shown that certain brain ...

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Generation of mouse induced pluripotent stem cells succeeds better without Oct4

11-Nov-2019

Quality of induced pluripotent stem cells is dramatically enhanced by omitting what was thought to be the most crucial reprogramming factor. Scientists at the Max Planck Institute for Molecular Biomedicine in Münster showed that Oct4, a factor most commonly used for reprogramming, is detrimental ...

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Genetic diversity facilitates cancer therapy

Cancer patients with more different HLA genes respond better to treatment

11-Nov-2019

The constant battle against infectious pathogens has had a decisive influence on the human immune system over the course of our evolution. A key role in our adaptation to pathogens is played by HLA molecules. These proteins activate the immune system by presenting it with fragments of pathogens ...

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Oxygen deficiency rewires mitochondria

Researchers slow the growth of pancreatic tumour cells

08-Nov-2019

Mitochondria burn oxygen and provide energy for the body. Cells lacking oxygen or nutrients have to change their energy supply quickly in order to keep growing. In a study published in Nature, scientists from the Max Planck Institute for Biology of Ageing have now shown that mitochondria are ...

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What and how much we eat might change our internal clocks and hormone responses

08-Nov-2019

For the first time, a study led by researchers at Helmholtz Zentrum München and the German Center for Diabetes Research (DZD) shows how glucocorticoid hormones, such as cortisol, control sugar and fat levels differently during day and night, feeding and fasting, rest and activity, over the course ...

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How cells stick together tightly

07-Nov-2019

Our organs are specialized compartments, each with its own milieu and function. To seal our organs, the cells in the tissue must form a barrier which is tight even down to the level of molecules. This barrier is formed by a protein complex that “sticks” all the cells together without any gaps. ...

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