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Misfolded Proteins

News Misfolded Proteins

  • Sensing Protein Wellbeing

    The folding state of the proteins in live cells often reflect the cell’s general health. Australian scientists have developed a molecular probe that senses the state of the proteome—the entire set of the proteins—by measuring the polarity of the protein environment. The fluorescence signal of the pr more

  • New drug candidates reverse drug resistance in multiple myeloma in preclinical models

    In an article Medical University of South Carolina investigators report that a new compound enhances the efficacy of proteasome inhibitors (PIs), the standard-of-care for the treatment of multiple myeloma (MM), in cell culture and in preclinical models. The efficacy and safety of the novel combinati more

  • A new way to stimulate cellular recycling process

    Brown University researchers studying the biology of aging have demonstrated a new strategy for stimulating autophagy, the process by which cells rebuild themselves by recycling their own worn-out parts. In a study the researchers show that the approach increased the lifespans of worms and flies, an more

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