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Tyrocidine is a class of naturally occurring antibiotics produced by some strains of Bacillus brevis.
Additional recommended knowledge
Tyrocidines A, B, and C are cyclic decapeptides. The biosynthesis of tyrocidine involves three enzymes. Parts of its sequence are identical to gramicidin S.
Tyrocidine A: D-Phe L-Pro L-Phe D-Phe L-Asn L-Gln L-Tyr L-Val L-Orn L-Leu Tyrocidine B: D-Phe L-Pro L-Trp D-Phe L-Asn L-Gln L-Tyr L-Val L-Orn L-Leu Tyrocidine C: D-Phe L-Pro L-Trp D-Trp L-Asn L-Gln L-Tyr L-Val L-Orn L-Leu Tyrocidine D: D-Phe L-Pro L-Trp D-Trp L-Asn L-Gln L-Trp L-Val L-Orn L-Leu
Tyrocidine and gramicidin are the constituents of tyrothricin, which was originally isolated by René Dubos in 1939, and was the first commercially produced antibiotic. It is used as a topical application; toxicity prevents systemic use. Dubos's discovery helped revive interest in research on penicillin.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Tyrocidine". A list of authors is available in Wikipedia.|