My watch list  

Tetrahydrofolic acid

Tetrahydrofolic acid
CAS number 29347-89-5
PubChem 1129
MeSH 5,6,7,8-tetrahydrofolic+acid
Molecular formula C19H23N7O6
Molar mass 445.43 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Tetrahydrofolic acid is a folic acid derivative.


  It is produced from dihydrofolic acid by dihydrofolate reductase. This reaction is inhibited by trimethoprim.

It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase.


It is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids. It acts as a donor of a group with one carbon atom. It gets this carbon atom by sequestering formaldehyde produced in other processes. A shortage in THF can cause anemia.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Tetrahydrofolic_acid". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE