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Intraglomerular mesangial cell
Additional recommended knowledge
There are three primary functions of intraglomerular mesangial cells: filtration, structural support, and phagocytosis.
Filtration and structure
They provide structural support for and regulate blood flow of the glomerular capillaries by their contractile activity. The initiation of contraction of mesangial cells is similar to that of smooth muscle. Contraction of mesangial cells is coupled by that of basement membrane of the endothelium of glomerular capillaries, causing decrease in surface area of basement membrane. Thus, decreasing glomerular filtration rate.
Mesangial cells also phagocytose glomerular basal lamina components and immunoglobulins. They are an unusual example of phagocytic cells derived from smooth muscle and not monocytes.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Intraglomerular_mesangial_cell". A list of authors is available in Wikipedia.|