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HLA-A25



major histocompatibility complex (human), class I, A25
Alleles A*2501
A*2502
Structure (See HLA-A)
Identifiers
2501 2502
Symbol(s) HLA-A
EBI-HLA A*2501
EBI-HLA A*2502
Shared data
Locus chr.6 6p21.31

HLA-A25 (A25) is an HLA-A serotype. The serotype identifies the more common HLA-A*25 gene products. A25 is a split antigen of the A10 broad antigen serotype group. It is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[1] A26 is more common in Western Europe.


Serotype

A25 and A10 serotype recognition of HLA A*2501 allele-group gene products[2]
A*25 A25 A10 Sample
allele % % size (N)
2501 95 2 1375
2502 80 5

There are 7 alleles for A25, 6 that result in different isoforms.

A25 frequencies

HLA A*2501 frequencies
freq
ref. Population (%)
[3] Saudi Arabia5.7
[3] India Jalpaiguri Toto5.2
[3] Russia Northwest5.0
[3] Spain Pas Valley4.3
[3] Czech Republic4.2
[3] Spain North Cantabrian4.2
[3] Russia Arkhangelsk Pomors4.0
[3] Croatia 3.9
[3] Spain North Cabuernigo3.8
[3] Russia Chuvash3.7
[3] Romanian3.5
[3] Italy Bergamo3.2
[3] Croatia 3.0
[3] Israel Ashkenazi Jews 2.8
[3] Bulgaria 2.7
[3] Spain Basque Arratia Valley 2.7
[3] Sweden Uppsala County 2.6
[3] Ireland Northern2.1
[3] Turkey 2.1
[3] Wales2.1
[3] Spain Eastern Andalusia 2.0
[3] Georgia Svaneti Svans1.9
[3] Italy1.9
[3] England Manchester1.9
[3] England Lancaster1.8
[3] Jews (Israel)1.7
[3] Macedonia1.7
[3] England Sheffield1.6
[3] Portugal South pop21.4
[3] Italy South Campania1.2
[3] Uganda Kampala1.2
[3] Finland1.1
[3] Portugal North1.1
[3] Belgium 1.0
[3] France Corsica1.0
[3] Mongolia Oold1.0
[3] Russia Murmansk Saomi1.0
[3] Tunisia 1.0
[3] France South East0.8
[3] Morocco Nador Metalsa0.7
[3] Greece 0.6
[3] Italy North Pavia0.6
[3] Algeria0.5
[3] China Qinghai Hui0.5
[3] Guatemala Mayans0.4
[3] Russia Nenets0.4
[3] Cameroon Beti0.3
[3] Beijing Shijiazhuang0.1
[3] Taiwan Hakka0.1

A*2501 distribution is primarily located in western Eurasia. Frequency tends to be highest in the populations that underwent later neolithization suggesting A*2501 spread in Europe. The high frequency in Saudi Arabia is suggestive of a source.

References

  1. ^ Madrigal JA, Hildebrand WH, Belich MP, et al (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens 41 (2): 72-80. PMID 8475492.
  2. ^ derived from IMGT/HLA
  3. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-A25". A list of authors is available in Wikipedia.
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