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HLA-A74



major histocompatibility complex (human), class I, A74
Alleles A*7401
A*7403
Structure (See HLA-A)
Identifiers
7401 7403
Symbol(s) HLA-A
EBI-HLA A*7401
EBI-HLA A*7403
Shared data
Locus chr.6 6p21.31

HLA-A74 (A74) is an HLA-A serotype. The serotype identifies the HLA-A*7401 gene product. A74 is a split antigen type of the A19 broad antigen type. A74 is rare.


Contents

Serotype

A74, A19 serotype recognition of Some HLA A*74 allele-group gene products[1]
A*74 A74 A19 Sample
allele % % size (N)
7401 40 11 119
7401 17 29


Disease associations

A significant association has been found between A74 and nasal polyposis.[2]

A*74 allele Frequencies

HLA A*7401 frequencies
freq
ref. Population (%)
[3] Kenya9.7
[3] Cameroon Beti8.3
[3] Guinea Bissau7.7
[3] Burkina Faso Mossi6.6
[3] Uganda Kampala5.2
[3] Cameroon Yaounde5.0
[3] Cameroon Bamileke 4.5
[3] Cameroon Sawa3.8
[3] Mali Bandiagara3.6
[3] Iran Baloch2.8
[3] Zimbabwe Harare Shona2.7
[3] Senegal Niokholo Mandenka2.2
[3] Burkina Faso Rimaibe2.1
[3] Kenya Nandi1.7
[3] Morocco Nador Metalsa 1.4
[3] Thailand Northeast1.2
[3] Thailand1.1
[3] Jordon Amman0.7
[3] Jordon Amman0.5
[3] China South0.5
HLA A*7403 frequencies
freq
ref. Population (%)
[3] Kenya Luo7.3
[3] Iran Baloch0.6
[3] Kenya0.3
[3] Uganda Kampala0.3

References

  1. ^ derived from IMGT/HLA
  2. ^ Luxenberger W, Posch U, Berghold A, Hofmann T, Lang-Loidolt D (2000). "HLA patterns in patients with nasal polyposis". European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 257 (3): 137–9. PMID 10839486.
  3. ^ a b c d e f g h i j k l m n o p q r s t u v w x Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-A74". A list of authors is available in Wikipedia.
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