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The mechanism underlying this behavior is thought to involve the effect of the electric field on receptors and membrane proteins on the cell's surface. These charged proteins would experience an electrophoretic force pulling them toward the oppositely charged pole of the electric field. Most of these membrane proteins are negatively charged, but the growth, when observed appears to be directed to the negative pole (cathode). This is a strange behavior that can only be accounted for by electroosmotic effects. Positively charged ions outside the cell experience a force towards the cathode. There is a flux of these ions outside the cell and the shear force of solution movement is thought to pull the neurite in the cathodal direction. Also, the electric field may depolarize the cell near the cathodal side opening voltage-gated calcium channels and allowing calcium ions to enter the cell. Calcium is widely believed to be a factor in neurite outgrowth. This theory has been challenged in a recent paper by scientists at Purdue University. Recent studies also involve differentiating between the effect of current on growth direction and the effect of a simple electric field. Studies involving AC and DC fields are also being conducted.
This is currently a highly researched topic, in which many neuroscience labs around the world are attempting to be the first to have a feasible method of directing outgrowth. Potential applications involve the direction and regeneration of severed nerves although these would only become available in the very distant future. This technique would also be useful in the study of neuronal networks. Neurites could be directed toward each other over large distances and allowed to form synapses. Networks of hundreds or thousands of cells could constructed and studied.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Galvanotropism". A list of authors is available in Wikipedia.|